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Anti-amyloid treatment is broadly effective in neuronopathic mucopolysaccharidoses and synergizes with gene therapy in MPS-IIIA.
Giaccio M, Monaco A, Galiano L, Parente A, Borzacchiello L, Rubino R, Klärner FG, Killa D, Perna C, Piccolo P, Marotta M, Pan X, Khijniak M, Siddique I, Schrader T, Pshezhetsky AV, Sorrentino NC, Bitan G, Fraldi A. Giaccio M, et al. Among authors: schrader t. Mol Ther. 2024 Nov 6;32(11):4108-4121. doi: 10.1016/j.ymthe.2024.09.030. Epub 2024 Sep 28. Mol Ther. 2024. PMID: 39342429 Free PMC article.
New insights into the functions of ACBD4/5-like proteins using a combined phylogenetic and experimental approach across model organisms.
Kors S, Schuster M, Maddison DC, Kilaru S, Schrader TA, Costello JL, Islinger M, Smith GA, Schrader M. Kors S, et al. Among authors: schrader ta. Biochim Biophys Acta Mol Cell Res. 2024 Dec;1871(8):119843. doi: 10.1016/j.bbamcr.2024.119843. Epub 2024 Sep 11. Biochim Biophys Acta Mol Cell Res. 2024. PMID: 39271061 Free article.
Functional Linkers Support Targeting of Multivalent Tweezers to Taspase1.
Hommel K, Kauth AA, Kirupakaran A, Theisen S, Hayduk M, Niemeyer FC, Beuck C, Zadmard R, Bayer P, Jan Ravoo B, Voskuhl J, Schrader T, Knauer SK. Hommel K, et al. Among authors: schrader t. Chemistry. 2024 Oct 8;30(56):e202401542. doi: 10.1002/chem.202401542. Epub 2024 Sep 3. Chemistry. 2024. PMID: 38958349
Discovery of a brain penetrant small molecule antagonist targeting LPA1 receptors to reduce neuroinflammation and promote remyelination in multiple sclerosis.
Poon MM, Lorrain KI, Stebbins KJ, Edu GC, Broadhead AR, Lorenzana AO, Paulson BE, Baccei CS, Roppe JR, Schrader TO, Valdez LJ, Xiong Y, Chen AC, Lorrain DS. Poon MM, et al. Among authors: schrader to. Sci Rep. 2024 May 8;14(1):10573. doi: 10.1038/s41598-024-61369-9. Sci Rep. 2024. PMID: 38719983 Free PMC article.
A redox switch allows binding of Fe(II) and Fe(III) ions in the cyanobacterial iron-binding protein FutA from Prochlorococcus.
Bolton R, Machelett MM, Stubbs J, Axford D, Caramello N, Catapano L, Malý M, Rodrigues MJ, Cordery C, Tizzard GJ, MacMillan F, Engilberge S, von Stetten D, Tosha T, Sugimoto H, Worrall JAR, Webb JS, Zubkov M, Coles S, Mathieu E, Steiner RA, Murshudov G, Schrader TE, Orville AM, Royant A, Evans G, Hough MA, Owen RL, Tews I. Bolton R, et al. Among authors: schrader te. Proc Natl Acad Sci U S A. 2024 Mar 19;121(12):e2308478121. doi: 10.1073/pnas.2308478121. Epub 2024 Mar 15. Proc Natl Acad Sci U S A. 2024. PMID: 38489389 Free PMC article.
344 results