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The proteasome participates in degradation of mutant alpha 1-antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytes.
Teckman JH, Burrows J, Hidvegi T, Schmidt B, Hale PD, Perlmutter DH. Teckman JH, et al. J Biol Chem. 2001 Nov 30;276(48):44865-72. doi: 10.1074/jbc.M103703200. Epub 2001 Sep 27. J Biol Chem. 2001. PMID: 11577074 Free article.
In previous studies using stable transfected human fibroblast cell lines and a cell-free microsomal translocation system, we found evidence for involvement of the proteasome in degradation of alpha(1)-ATZ (Qu, D., Teckman, J. H., Omura, S., and Perlmutter, D. H. (19 …
In previous studies using stable transfected human fibroblast cell lines and a cell-free microsomal translocation system, we found evidence …
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