The proteasome participates in degradation of mutant alpha 1-antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytes.
Teckman JH, Burrows J, Hidvegi T, Schmidt B, Hale PD, Perlmutter DH.
Teckman JH, et al.
J Biol Chem. 2001 Nov 30;276(48):44865-72. doi: 10.1074/jbc.M103703200. Epub 2001 Sep 27.
J Biol Chem. 2001.
PMID: 11577074
Free article.
In previous studies using stable transfected human fibroblast cell lines and a cell-free microsomal translocation system, we found evidence for involvement of the proteasome in degradation of alpha(1)-ATZ (Qu, D., Teckman, J. H., Omura, S., and Perlmutter, D. H. (19 …
In previous studies using stable transfected human fibroblast cell lines and a cell-free microsomal translocation system, we found evidence …