Reddy JA - Search Results

1

Preclinical antitumor activity of a novel folate-targeted dual drug conjugate.

Leamon CP, Reddy JA, Vlahov IR, Westrick E, Dawson A, Dorton R, Vetzel M, Santhapuram HK, Wang Y. Leamon CP, et al. Among authors: reddy ja. Mol Pharm. 2007 Sep-Oct;4(5):659-67. doi: 10.1021/mp070049c. Epub 2007 Sep 18. Mol Pharm. 2007. PMID: 17874843

2

Synthesis and biological evaluation of EC72: a new folate-targeted chemotherapeutic.

Leamon CP, Reddy JA, Vlahov IR, Vetzel M, Parker N, Nicoson JS, Xu LC, Westrick E. Leamon CP, et al. Among authors: reddy ja. Bioconjug Chem. 2005 Jul-Aug;16(4):803-11. doi: 10.1021/bc049709b. Bioconjug Chem. 2005. PMID: 16029021

3

Folate receptor specific anti-tumor activity of folate-mitomycin conjugates.

Reddy JA, Westrick E, Vlahov I, Howard SJ, Santhapuram HK, Leamon CP. Reddy JA, et al. Cancer Chemother Pharmacol. 2006 Aug;58(2):229-36. doi: 10.1007/s00280-005-0151-z. Epub 2005 Dec 6. Cancer Chemother Pharmacol. 2006. PMID: 16331500

4

Synthesis and biological evaluation of EC140: a novel folate-targeted vinca alkaloid conjugate.

Leamon CP, Reddy JA, Vlahov IR, Kleindl PJ, Vetzel M, Westrick E. Leamon CP, et al. Among authors: reddy ja. Bioconjug Chem. 2006 Sep-Oct;17(5):1226-32. doi: 10.1021/bc060145g. Bioconjug Chem. 2006. PMID: 16984132

5

Preclinical pharmacokinetics, tissue distribution, and antitumor activity of a folate-hapten conjugate-targeted immunotherapy in hapten-immunized mice.

Lu Y, Xu LC, Parker N, Westrick E, Reddy JA, Vetzel M, Low PS, Leamon CP. Lu Y, et al. Among authors: reddy ja. Mol Cancer Ther. 2006 Dec;5(12):3258-67. doi: 10.1158/1535-7163.MCT-06-0439. Mol Cancer Ther. 2006. PMID: 17172429

6

Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate.

Reddy JA, Dorton R, Westrick E, Dawson A, Smith T, Xu LC, Vetzel M, Kleindl P, Vlahov IR, Leamon CP. Reddy JA, et al. Cancer Res. 2007 May 1;67(9):4434-42. doi: 10.1158/0008-5472.CAN-07-0033. Cancer Res. 2007. PMID: 17483358

7

Comparative preclinical activity of the folate-targeted Vinca alkaloid conjugates EC140 and EC145.

Leamon CP, Reddy JA, Vlahov IR, Westrick E, Parker N, Nicoson JS, Vetzel M. Leamon CP, et al. Among authors: reddy ja. Int J Cancer. 2007 Oct 1;121(7):1585-92. doi: 10.1002/ijc.22853. Int J Cancer. 2007. PMID: 17551919

8

An assembly concept for the consecutive introduction of unsymmetrical disulfide bonds: synthesis of a releasable multidrug conjugate of folic acid.

Vlahov IR, Santhapuram HK, Wang Y, Kleindl PJ, You F, Howard SJ, Westrick E, Reddy JA, Leamon CP. Vlahov IR, et al. Among authors: reddy ja. J Org Chem. 2007 Aug 3;72(16):5968-72. doi: 10.1021/jo070411z. Epub 2007 Jun 29. J Org Chem. 2007. PMID: 17602528

9

Folate receptor-specific antitumor activity of EC131, a folate-maytansinoid conjugate.

Reddy JA, Westrick E, Santhapuram HK, Howard SJ, Miller ML, Vetzel M, Vlahov I, Chari RV, Goldmacher VS, Leamon CP. Reddy JA, et al. Cancer Res. 2007 Jul 1;67(13):6376-82. doi: 10.1158/0008-5472.CAN-06-3894. Cancer Res. 2007. PMID: 17616697

10

Impact of high and low folate diets on tissue folate receptor levels and antitumor responses toward folate-drug conjugates.

Leamon CP, Reddy JA, Dorton R, Bloomfield A, Emsweller K, Parker N, Westrick E. Leamon CP, et al. Among authors: reddy ja. J Pharmacol Exp Ther. 2008 Dec;327(3):918-25. doi: 10.1124/jpet.108.143206. Epub 2008 Sep 12. J Pharmacol Exp Ther. 2008. PMID: 18791065

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