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Low-dose renin inhibitor and low-dose AT(1)-receptor blocker therapy ameliorate target-organ damage in rats harbouring human renin and angiotensinogen genes.
Dechend R, Shagdarsuren E, Gratze P, Fiebeler A, Pilz B, Meiners S, Derer W, Feldman DL, Webb R, Muller DN. Dechend R, et al. Among authors: feldman dl. J Renin Angiotensin Aldosterone Syst. 2007 Jun;8(2):81-4. doi: 10.3317/jraas.2007.008. J Renin Angiotensin Aldosterone Syst. 2007. PMID: 17703434 Free article.
The direct renin inhibitor aliskiren localizes and persists in rat kidneys.
Feldman DL, Jin L, Xuan H, Persohn E, Zhou W, Schuetz H, Park JK, Muller DN, Luft FC. Feldman DL, et al. Am J Physiol Renal Physiol. 2013 Dec 1;305(11):F1593-602. doi: 10.1152/ajprenal.00655.2012. Epub 2013 Aug 7. Am J Physiol Renal Physiol. 2013. PMID: 23926182 Free article.
Angiotensinogen Exerts Effects Independent of Angiotensin II.
Lu H, Wu C, Howatt DA, Balakrishnan A, Moorleghen JJ, Chen X, Zhao M, Graham MJ, Mullick AE, Crooke RM, Feldman DL, Cassis LA, Vander Kooi CW, Daugherty A. Lu H, et al. Among authors: feldman dl. Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):256-65. doi: 10.1161/ATVBAHA.115.306740. Epub 2015 Dec 17. Arterioscler Thromb Vasc Biol. 2016. PMID: 26681751 Free PMC article.
The renin rise with aliskiren: it's simply stoichiometry.
Danser AH, Charney A, Feldman DL, Nussberger J, Fisher N, Hollenberg N. Danser AH, et al. Among authors: feldman dl. Hypertension. 2008 Apr;51(4):e27-8; author reply e29. doi: 10.1161/HYPERTENSIONAHA.108.109967. Epub 2008 Feb 19. Hypertension. 2008. PMID: 18285609 No abstract available.
57 results