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N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics.
Bamborough P, Angell RM, Bhamra I, Brown D, Bull J, Christopher JA, Cooper AW, Fazal LH, Giordano I, Hind L, Patel VK, Ranshaw LE, Sims MJ, Skone PA, Smith KJ, Vickerstaff E, Washington M. Bamborough P, et al. Among authors: sims mj. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4363-8. doi: 10.1016/j.bmcl.2007.04.029. Epub 2007 Apr 13. Bioorg Med Chem Lett. 2007. PMID: 17600705
Mechanistic medicine: novel strategies for clinical trials.
Itano AA, Sims MJ, Siu G. Itano AA, et al. Among authors: sims mj. Autoimmunity. 2010 Nov;43(7):560-71. doi: 10.3109/08916931003674782. Epub 2010 Apr 30. Autoimmunity. 2010. PMID: 20429849 Free article. Review.
Requirement for CD28 co-stimulation is lower in SHP-1-deficient T cells.
Sathish JG, Johnson KG, LeRoy FG, Fuller KJ, Hallett MB, Brennan P, Borysiewicz LK, Sims MJ, Matthews RJ. Sathish JG, et al. Among authors: sims mj. Eur J Immunol. 2001 Dec;31(12):3649-58. doi: 10.1002/1521-4141(200112)31:12<3649::aid-immu3649>3.0.co;2-8. Eur J Immunol. 2001. PMID: 11745385 Free article.
Ligation of CD28 stimulates the formation of a multimeric signaling complex involving grb-2-associated binder 2 (gab2), SRC homology phosphatase-2, and phosphatidylinositol 3-kinase: evidence that negative regulation of CD28 signaling requires the gab2 pleckstrin homology domain.
Parry RV, Whittaker GC, Sims M, Edmead CE, Welham MJ, Ward SG. Parry RV, et al. Among authors: sims m. J Immunol. 2006 Jan 1;176(1):594-602. doi: 10.4049/jimmunol.176.1.594. J Immunol. 2006. PMID: 16365455
33 results