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Slc7a9 knockout mouse is a good cystinuria model for antilithiasic pharmacological studies.
Font-Llitjós M, Feliubadaló L, Espino M, Clèries R, Mañas S, Frey IM, Puertas S, Colell G, Palomo S, Aranda J, Visa J, Palacín M, Nunes V. Font-Llitjós M, et al. Among authors: frey im. Am J Physiol Renal Physiol. 2007 Sep;293(3):F732-40. doi: 10.1152/ajprenal.00121.2007. Epub 2007 Jun 27. Am J Physiol Renal Physiol. 2007. PMID: 17596531 Free article.
Profiling at mRNA, protein, and metabolite levels reveals alterations in renal amino acid handling and glutathione metabolism in kidney tissue of Pept2-/- mice.
Frey IM, Rubio-Aliaga I, Siewert A, Sailer D, Drobyshev A, Beckers J, de Angelis MH, Aubert J, Bar Hen A, Fiehn O, Eichinger HM, Daniel H. Frey IM, et al. Physiol Genomics. 2007 Feb 12;28(3):301-10. doi: 10.1152/physiolgenomics.00193.2006. Epub 2006 Oct 31. Physiol Genomics. 2007. PMID: 17077276