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HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates.
Wille-Reece U, Flynn BJ, Loré K, Koup RA, Kedl RM, Mattapallil JJ, Weiss WR, Roederer M, Seder RA. Wille-Reece U, et al. Among authors: flynn bj. Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15190-4. doi: 10.1073/pnas.0507484102. Epub 2005 Oct 11. Proc Natl Acad Sci U S A. 2005. PMID: 16219698 Free PMC article.
Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and αDEC-CSP in non human primates.
Tewari K, Flynn BJ, Boscardin SB, Kastenmueller K, Salazar AM, Anderson CA, Soundarapandian V, Ahumada A, Keler T, Hoffman SL, Nussenzweig MC, Steinman RM, Seder RA. Tewari K, et al. Among authors: flynn bj. Vaccine. 2010 Oct 21;28(45):7256-66. doi: 10.1016/j.vaccine.2010.08.098. Epub 2010 Sep 21. Vaccine. 2010. PMID: 20846528 Free PMC article.
Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates.
Flynn BJ, Kastenmüller K, Wille-Reece U, Tomaras GD, Alam M, Lindsay RW, Salazar AM, Perdiguero B, Gomez CE, Wagner R, Esteban M, Park CG, Trumpfheller C, Keler T, Pantaleo G, Steinman RM, Seder R. Flynn BJ, et al. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7131-6. doi: 10.1073/pnas.1103869108. Epub 2011 Apr 5. Proc Natl Acad Sci U S A. 2011. PMID: 21467219 Free PMC article.
Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets.
Kastenmüller K, Wille-Reece U, Lindsay RW, Trager LR, Darrah PA, Flynn BJ, Becker MR, Udey MC, Clausen BE, Igyarto BZ, Kaplan DH, Kastenmüller W, Germain RN, Seder RA. Kastenmüller K, et al. Among authors: flynn bj. J Clin Invest. 2011 May;121(5):1782-96. doi: 10.1172/JCI45416. Epub 2011 Apr 11. J Clin Invest. 2011. PMID: 21540549 Free PMC article.
Coadministration of polyinosinic:polycytidylic acid and immunostimulatory complexes modifies antigen processing in dendritic cell subsets and enhances HIV gag-specific T cell immunity.
Quinn KM, Yamamoto A, Costa A, Darrah PA, Lindsay RW, Hegde ST, Johnson TR, Flynn BJ, Loré K, Seder RA. Quinn KM, et al. Among authors: flynn bj. J Immunol. 2013 Nov 15;191(10):5085-96. doi: 10.4049/jimmunol.1301730. Epub 2013 Oct 2. J Immunol. 2013. PMID: 24089189 Free PMC article.
Analysis of immunoglobulin transcripts and hypermutation following SHIV(AD8) infection and protein-plus-adjuvant immunization.
Francica JR, Sheng Z, Zhang Z, Nishimura Y, Shingai M, Ramesh A, Keele BF, Schmidt SD, Flynn BJ, Darko S, Lynch RM, Yamamoto T, Matus-Nicodemos R, Wolinsky D; NISC Comparative Sequencing Program; Nason M, Valiante NM, Malyala P, De Gregorio E, Barnett SW, Singh M, O'Hagan DT, Koup RA, Mascola JR, Martin MA, Kepler TB, Douek DC, Shapiro L, Seder RA. Francica JR, et al. Among authors: flynn bj. Nat Commun. 2015 Apr 10;6:6565. doi: 10.1038/ncomms7565. Nat Commun. 2015. PMID: 25858157 Free PMC article.
72 results