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Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors.
Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin CE, Brenner GJ, Rubino T, Michalski CW, Marsicano G, Monory K, Mackie K, Marian C, Batkai S, Parolaro D, Fischer MJ, Reeh P, Kunos G, Kress M, Lutz B, Woolf CJ, Kuner R. Agarwal N, et al. Among authors: constantin ce. Nat Neurosci. 2007 Jul;10(7):870-9. doi: 10.1038/nn1916. Epub 2007 Jun 10. Nat Neurosci. 2007. PMID: 17558404 Free PMC article.
Inhibitor kappaB Kinase beta deficiency in primary nociceptive neurons increases TRP channel sensitivity.
Bockhart V, Constantin CE, Häussler A, Wijnvoord N, Kanngiesser M, Myrczek T, Pickert G, Popp L, Sobotzik JM, Pasparakis M, Kuner R, Geisslinger G, Schultz C, Kress M, Tegeder I. Bockhart V, et al. Among authors: constantin ce. J Neurosci. 2009 Oct 14;29(41):12919-29. doi: 10.1523/JNEUROSCI.1496-09.2009. J Neurosci. 2009. PMID: 19828806 Free PMC article.
Gα(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization.
Tappe-Theodor A, Constantin CE, Tegeder I, Lechner SG, Langeslag M, Lepcynzsky P, Wirotanseng RI, Kurejova M, Agarwal N, Nagy G, Todd A, Wettschureck N, Offermanns S, Kress M, Lewin GR, Kuner R. Tappe-Theodor A, et al. Among authors: constantin ce. Pain. 2012 Jan;153(1):184-196. doi: 10.1016/j.pain.2011.10.014. Epub 2011 Nov 8. Pain. 2012. PMID: 22071319
A key role for gp130 expressed on peripheral sensory nerves in pathological pain.
Andratsch M, Mair N, Constantin CE, Scherbakov N, Benetti C, Quarta S, Vogl C, Sailer CA, Uceyler N, Brockhaus J, Martini R, Sommer C, Zeilhofer HU, Müller W, Kuner R, Davis JB, Rose-John S, Kress M. Andratsch M, et al. Among authors: constantin ce. J Neurosci. 2009 Oct 28;29(43):13473-83. doi: 10.1523/JNEUROSCI.1822-09.2009. J Neurosci. 2009. PMID: 19864560 Free PMC article.
13 results