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Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.
Maser RS, Choudhury B, Campbell PJ, Feng B, Wong KK, Protopopov A, O'Neil J, Gutierrez A, Ivanova E, Perna I, Lin E, Mani V, Jiang S, McNamara K, Zaghlul S, Edkins S, Stevens C, Brennan C, Martin ES, Wiedemeyer R, Kabbarah O, Nogueira C, Histen G, Aster J, Mansour M, Duke V, Foroni L, Fielding AK, Goldstone AH, Rowe JM, Wang YA, Look AT, Stratton MR, Chin L, Futreal PA, DePinho RA. Maser RS, et al. Nature. 2007 Jun 21;447(7147):966-71. doi: 10.1038/nature05886. Epub 2007 May 21. Nature. 2007. PMID: 17515920 Free PMC article.
Alu elements mediate MYB gene tandem duplication in human T-ALL.
O'Neil J, Tchinda J, Gutierrez A, Moreau L, Maser RS, Wong KK, Li W, McKenna K, Liu XS, Feng B, Neuberg D, Silverman L, DeAngelo DJ, Kutok JL, Rothstein R, DePinho RA, Chin L, Lee C, Look AT. O'Neil J, et al. J Exp Med. 2007 Dec 24;204(13):3059-66. doi: 10.1084/jem.20071637. Epub 2007 Dec 10. J Exp Med. 2007. PMID: 18070937 Free PMC article.
Activating Notch1 mutations in mouse models of T-ALL.
O'Neil J, Calvo J, McKenna K, Krishnamoorthy V, Aster JC, Bassing CH, Alt FW, Kelliher M, Look AT. O'Neil J, et al. Blood. 2006 Jan 15;107(2):781-5. doi: 10.1182/blood-2005-06-2553. Epub 2005 Sep 15. Blood. 2006. PMID: 16166587 Free PMC article.
Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.
Rao SS, O'Neil J, Liberator CD, Hardwick JS, Dai X, Zhang T, Tyminski E, Yuan J, Kohl NE, Richon VM, Van der Ploeg LH, Carroll PM, Draetta GF, Look AT, Strack PR, Winter CG. Rao SS, et al. Cancer Res. 2009 Apr 1;69(7):3060-8. doi: 10.1158/0008-5472.CAN-08-4295. Epub 2009 Mar 24. Cancer Res. 2009. PMID: 19318552
724 results