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Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans.
Yang Y, Chung EK, Wu YL, Savelli SL, Nagaraja HN, Zhou B, Hebert M, Jones KN, Shu Y, Kitzmiller K, Blanchong CA, McBride KL, Higgins GC, Rennebohm RM, Rice RR, Hackshaw KV, Roubey RA, Grossman JM, Tsao BP, Birmingham DJ, Rovin BH, Hebert LA, Yu CY. Yang Y, et al. Am J Hum Genet. 2007 Jun;80(6):1037-54. doi: 10.1086/518257. Epub 2007 Apr 26. Am J Hum Genet. 2007. PMID: 17503323 Free PMC article.
Three distinct profiles of serum complement C4 proteins in pediatric systemic lupus erythematosus (SLE) patients: tight associations of complement C4 and C3 protein levels in SLE but not in healthy subjects.
Wu YL, Higgins GC, Rennebohm RM, Chung EK, Yang Y, Zhou B, Nagaraja HN, Birmingham DJ, Rovin BH, Hebert LA, Yu CY. Wu YL, et al. Among authors: yang y. Adv Exp Med Biol. 2006;586:227-47. doi: 10.1007/0-387-34134-X_16. Adv Exp Med Biol. 2006. PMID: 16893076
Sensitive and specific real-time polymerase chain reaction assays to accurately determine copy number variations (CNVs) of human complement C4A, C4B, C4-long, C4-short, and RCCX modules: elucidation of C4 CNVs in 50 consanguineous subjects with defined HLA genotypes.
Wu YL, Savelli SL, Yang Y, Zhou B, Rovin BH, Birmingham DJ, Nagaraja HN, Hebert LA, Yu CY. Wu YL, et al. Among authors: yang y. J Immunol. 2007 Sep 1;179(5):3012-25. doi: 10.4049/jimmunol.179.5.3012. J Immunol. 2007. PMID: 17709516
Great genotypic and phenotypic diversities associated with copy-number variations of complement C4 and RP-C4-CYP21-TNX (RCCX) modules: a comparison of Asian-Indian and European American populations.
Saxena K, Kitzmiller KJ, Wu YL, Zhou B, Esack N, Hiremath L, Chung EK, Yang Y, Yu CY. Saxena K, et al. Among authors: yang y. Mol Immunol. 2009 Apr;46(7):1289-303. doi: 10.1016/j.molimm.2008.11.018. Epub 2009 Jan 9. Mol Immunol. 2009. PMID: 19135723 Free PMC article.
Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.
Chen JY, Wu YL, Mok MY, Wu YJ, Lintner KE, Wang CM, Chung EK, Yang Y, Zhou B, Wang H, Yu D, Alhomosh A, Jones K, Spencer CH, Nagaraja HN, Lau YL, Lau CS, Yu CY. Chen JY, et al. Among authors: yang y. Arthritis Rheumatol. 2016 Jun;68(6):1442-1453. doi: 10.1002/art.39589. Arthritis Rheumatol. 2016. PMID: 26814708 Free PMC article.
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