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Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis.
Izzo LT, Trefely S, Demetriadou C, Drummond JM, Mizukami T, Kuprasertkul N, Farria AT, Nguyen PTT, Murali N, Reich L, Kantner DS, Shaffer J, Affronti H, Carrer A, Andrews A, Capell BC, Snyder NW, Wellen KE. Izzo LT, et al. Among authors: wellen ke. Sci Adv. 2023 May 3;9(18):eadf0115. doi: 10.1126/sciadv.adf0115. Epub 2023 May 3. Sci Adv. 2023. PMID: 37134161 Free PMC article.
Metabolic Signaling in Cancer.
Pinheiro LV, Costa-Pinheiro P, Wellen KE. Pinheiro LV, et al. Among authors: wellen ke. Cold Spring Harb Perspect Med. 2024 Jun 10:a041544. doi: 10.1101/cshperspect.a041544. Online ahead of print. Cold Spring Harb Perspect Med. 2024. PMID: 38858082
Acly Deficiency Enhances Myelopoiesis through Acetyl Coenzyme A and Metabolic-Epigenetic Cross-Talk.
Greenwood DL, Ramsey HE, Nguyen PTT, Patterson AR, Voss K, Bader JE, Sugiura A, Bacigalupa ZA, Schaefer S, Ye X, Dahunsi DO, Madden MZ, Wellen KE, Savona MR, Ferrell PB, Rathmell JC. Greenwood DL, et al. Among authors: wellen ke. Immunohorizons. 2022 Dec 1;6(12):837-850. doi: 10.4049/immunohorizons.2200086. Immunohorizons. 2022. PMID: 36547387 Free PMC article.
Therapeutic targeting of ACLY in T-ALL in vivo.
da Silva-Diz V, Singh A, Aleksandrova M, Kim O, Thai C, Lancho O, Nunes PR, Affronti H, Su X, Wellen KE, Herranz D. da Silva-Diz V, et al. Among authors: wellen ke. bioRxiv [Preprint]. 2024 Jun 20:2023.03.27.534395. doi: 10.1101/2023.03.27.534395. bioRxiv. 2024. PMID: 37034581 Free PMC article. Preprint.
Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer.
Miller KD, O'Connor S, Pniewski KA, Kannan T, Acosta R, Mirji G, Papp S, Hulse M, Mukha D, Hlavaty SI, Salcido KN, Bertolazzi F, Srikanth YVV, Zhao S, Wellen KE, Shinde RS, Claiborne DT, Kossenkov A, Salvino JM, Schug ZT. Miller KD, et al. Among authors: wellen ke. Nat Cancer. 2023 Oct;4(10):1491-1507. doi: 10.1038/s43018-023-00636-6. Epub 2023 Sep 18. Nat Cancer. 2023. PMID: 37723305 Free PMC article.
Acetyl-CoA metabolism in cancer.
Guertin DA, Wellen KE. Guertin DA, et al. Among authors: wellen ke. Nat Rev Cancer. 2023 Mar;23(3):156-172. doi: 10.1038/s41568-022-00543-5. Epub 2023 Jan 19. Nat Rev Cancer. 2023. PMID: 36658431 Free PMC article. Review.
A subpopulation of lipogenic brown adipocytes drives thermogenic memory.
Lundgren P, Sharma PV, Dohnalová L, Coleman K, Uhr GT, Kircher S, Litichevskiy L, Bahnsen K, Descamps HC, Demetriadou C, Chan J, Chellappa K, Cox TO, Heyman Y, Pather SR, Shoffler C, Petucci C, Shalem O, Raj A, Baur JA, Snyder NW, Wellen KE, Levy M, Seale P, Li M, Thaiss CA. Lundgren P, et al. Among authors: wellen ke. Nat Metab. 2023 Oct;5(10):1691-1705. doi: 10.1038/s42255-023-00893-w. Epub 2023 Oct 2. Nat Metab. 2023. PMID: 37783943 Free PMC article.
93 results