Hessel EM - Search Results

1

Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists.

Kanzler H, Barrat FJ, Hessel EM, Coffman RL. Kanzler H, et al. Among authors: hessel em. Nat Med. 2007 May;13(5):552-9. doi: 10.1038/nm1589. Nat Med. 2007. PMID: 17479101 Review.

2

Biomarkers measuring the activity of Toll-like receptor ligands in clinical development programs.

Sims P, Coffman RL, Hessel EM. Sims P, et al. Among authors: hessel em. Methods Mol Biol. 2009;517:415-40. doi: 10.1007/978-1-59745-541-1_25. Methods Mol Biol. 2009. PMID: 19378019

3

Nonhuman primate models of asthma.

Coffman RL, Hessel EM. Coffman RL, et al. Among authors: hessel em. J Exp Med. 2005 Jun 20;201(12):1875-9. doi: 10.1084/jem.20050901. J Exp Med. 2005. PMID: 15967818 Free PMC article.

4

Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction.

Hessel EM, Chu M, Lizcano JO, Chang B, Herman N, Kell SA, Wills-Karp M, Coffman RL. Hessel EM, et al. J Exp Med. 2005 Dec 5;202(11):1563-73. doi: 10.1084/jem.20050631. Epub 2005 Nov 28. J Exp Med. 2005. PMID: 16314434 Free PMC article.

5

CpG-containing immunostimulatory DNA sequences elicit TNF-alpha-dependent toxicity in rodents but not in humans.

Campbell JD, Cho Y, Foster ML, Kanzler H, Kachura MA, Lum JA, Ratcliffe MJ, Sathe A, Leishman AJ, Bahl A, McHale M, Coffman RL, Hessel EM. Campbell JD, et al. Among authors: hessel em. J Clin Invest. 2009 Sep;119(9):2564-76. doi: 10.1172/JCI38294. Epub 2009 Aug 10. J Clin Invest. 2009. PMID: 19726873 Free PMC article.

6

Superior activity of the type C class of ISS in vitro and in vivo across multiple species.

Marshall JD, Fearon KL, Higgins D, Hessel EM, Kanzler H, Abbate C, Yee P, Gregorio J, Cruz TD, Lizcano JO, Zolotorev A, McClure HM, Brasky KM, Murthy KK, Coffman RL, Nest GV. Marshall JD, et al. Among authors: hessel em. DNA Cell Biol. 2005 Feb;24(2):63-72. doi: 10.1089/dna.2005.24.63. DNA Cell Biol. 2005. PMID: 15699627

7

A limited CpG-containing oligodeoxynucleotide therapy regimen induces sustained suppression of allergic airway inflammation in mice.

Campbell JD, Kell SA, Kozy HM, Lum JA, Sweetwood R, Chu M, Cunningham CR, Salamon H, Lloyd CM, Coffman RL, Hessel EM. Campbell JD, et al. Among authors: hessel em. Thorax. 2014 Jun;69(6):565-573. doi: 10.1136/thoraxjnl-2013-204605. Epub 2014 Jan 24. Thorax. 2014. PMID: 24464743 Free PMC article.

8

Novel chimeric immunomodulatory compounds containing short CpG oligodeoxyribonucleotides have differential activities in human cells.

Marshall JD, Hessel EM, Gregorio J, Abbate C, Yee P, Chu M, Van Nest G, Coffman RL, Fearon KL. Marshall JD, et al. Among authors: hessel em. Nucleic Acids Res. 2003 Sep 1;31(17):5122-33. doi: 10.1093/nar/gkg700. Nucleic Acids Res. 2003. PMID: 12930963 Free PMC article.

9

First-in-Human Study With the Inhaled TLR9 Oligonucleotide Agonist AZD1419 Results in Interferon Responses in the Lung, and Is Safe and Well-Tolerated.

Jackson S, Candia AF, Delaney S, Floettmann S, Wong C, Campbell JD, Kell S, Lum J, Hessel EM, Traquina P, McHale M, Robinson I, Bell J, Fuhr R, Keeling D, Coffman RL. Jackson S, et al. Among authors: hessel em. Clin Pharmacol Ther. 2018 Aug;104(2):335-345. doi: 10.1002/cpt.938. Epub 2017 Dec 6. Clin Pharmacol Ther. 2018. PMID: 29134633 Clinical Trial.

10

Allergen-specific T cell responses to immunotherapy monitored by CD154 and intracellular cytokine expression.

Campbell JD, Buchmann P, Kesting S, Cunningham CR, Coffman RL, Hessel EM. Campbell JD, et al. Among authors: hessel em. Clin Exp Allergy. 2010 Jul;40(7):1025-35. doi: 10.1111/j.1365-2222.2010.03505.x. Epub 2010 Apr 13. Clin Exp Allergy. 2010. PMID: 20412135 Clinical Trial.

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