Coffman RL - Search Results

1

Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists.

Kanzler H, Barrat FJ, Hessel EM, Coffman RL. Kanzler H, et al. Among authors: coffman rl. Nat Med. 2007 May;13(5):552-9. doi: 10.1038/nm1589. Nat Med. 2007. PMID: 17479101 Review.

2

Signalling pathways leading to IFN-alpha production in human plasmacytoid dendritic cell and the possible use of agonists or antagonists of TLR7 and TLR9 in clinical indications.

Guiducci C, Coffman RL, Barrat FJ. Guiducci C, et al. Among authors: coffman rl. J Intern Med. 2009 Jan;265(1):43-57. doi: 10.1111/j.1365-2796.2008.02050.x. J Intern Med. 2009. PMID: 19093959 Free article. Review.

3

Development of TLR inhibitors for the treatment of autoimmune diseases.

Barrat FJ, Coffman RL. Barrat FJ, et al. Among authors: coffman rl. Immunol Rev. 2008 Jun;223:271-83. doi: 10.1111/j.1600-065X.2008.00630.x. Immunol Rev. 2008. PMID: 18613842 Review.

4

Biomarkers measuring the activity of Toll-like receptor ligands in clinical development programs.

Sims P, Coffman RL, Hessel EM. Sims P, et al. Among authors: coffman rl. Methods Mol Biol. 2009;517:415-40. doi: 10.1007/978-1-59745-541-1_25. Methods Mol Biol. 2009. PMID: 19378019

5

TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus.

Guiducci C, Gong M, Xu Z, Gill M, Chaussabel D, Meeker T, Chan JH, Wright T, Punaro M, Bolland S, Soumelis V, Banchereau J, Coffman RL, Pascual V, Barrat FJ. Guiducci C, et al. Among authors: coffman rl. Nature. 2010 Jun 17;465(7300):937-41. doi: 10.1038/nature09102. Nature. 2010. PMID: 20559388 Free PMC article.

6

IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequences.

Duramad O, Fearon KL, Chan JH, Kanzler H, Marshall JD, Coffman RL, Barrat FJ. Duramad O, et al. Among authors: coffman rl. Blood. 2003 Dec 15;102(13):4487-92. doi: 10.1182/blood-2003-07-2465. Epub 2003 Aug 28. Blood. 2003. PMID: 12946990 Free article.

7

Nonhuman primate models of asthma.

Coffman RL, Hessel EM. Coffman RL, et al. J Exp Med. 2005 Jun 20;201(12):1875-9. doi: 10.1084/jem.20050901. J Exp Med. 2005. PMID: 15967818 Free PMC article.

8

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus.

Barrat FJ, Meeker T, Gregorio J, Chan JH, Uematsu S, Akira S, Chang B, Duramad O, Coffman RL. Barrat FJ, et al. Among authors: coffman rl. J Exp Med. 2005 Oct 17;202(8):1131-9. doi: 10.1084/jem.20050914. J Exp Med. 2005. PMID: 16230478 Free PMC article.

9

Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction.

Hessel EM, Chu M, Lizcano JO, Chang B, Herman N, Kell SA, Wills-Karp M, Coffman RL. Hessel EM, et al. Among authors: coffman rl. J Exp Med. 2005 Dec 5;202(11):1563-73. doi: 10.1084/jem.20050631. Epub 2005 Nov 28. J Exp Med. 2005. PMID: 16314434 Free PMC article.

10

Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation.

Guiducci C, Ott G, Chan JH, Damon E, Calacsan C, Matray T, Lee KD, Coffman RL, Barrat FJ. Guiducci C, et al. Among authors: coffman rl. J Exp Med. 2006 Aug 7;203(8):1999-2008. doi: 10.1084/jem.20060401. Epub 2006 Jul 24. J Exp Med. 2006. PMID: 16864658 Free PMC article.

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