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A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease.
Coon KD, Myers AJ, Craig DW, Webster JA, Pearson JV, Lince DH, Zismann VL, Beach TG, Leung D, Bryden L, Halperin RF, Marlowe L, Kaleem M, Walker DG, Ravid R, Heward CB, Rogers J, Papassotiropoulos A, Reiman EM, Hardy J, Stephan DA. Coon KD, et al. J Clin Psychiatry. 2007 Apr;68(4):613-8. doi: 10.4088/jcp.v68n0419. J Clin Psychiatry. 2007. PMID: 17474819
Identification of the genetic basis for complex disorders by use of pooling-based genomewide single-nucleotide-polymorphism association studies.
Pearson JV, Huentelman MJ, Halperin RF, Tembe WD, Melquist S, Homer N, Brun M, Szelinger S, Coon KD, Zismann VL, Webster JA, Beach T, Sando SB, Aasly JO, Heun R, Jessen F, Kolsch H, Tsolaki M, Daniilidou M, Reiman EM, Papassotiropoulos A, Hutton ML, Stephan DA, Craig DW. Pearson JV, et al. Among authors: coon kd. Am J Hum Genet. 2007 Jan;80(1):126-39. doi: 10.1086/510686. Epub 2006 Dec 6. Am J Hum Genet. 2007. PMID: 17160900 Free PMC article.
GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers.
Reiman EM, Webster JA, Myers AJ, Hardy J, Dunckley T, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Huentelman MJ, Craig DW, Coon KD, Liang WS, Herbert RH, Beach T, Rohrer KC, Zhao AS, Leung D, Bryden L, Marlowe L, Kaleem M, Mastroeni D, Grover A, Heward CB, Ravid R, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Kukull W, Papassotiropoulos A, Stephan DA. Reiman EM, et al. Among authors: coon kd. Neuron. 2007 Jun 7;54(5):713-20. doi: 10.1016/j.neuron.2007.05.022. Neuron. 2007. PMID: 17553421 Free PMC article.
Sorl1 as an Alzheimer's disease predisposition gene?
Webster JA, Myers AJ, Pearson JV, Craig DW, Hu-Lince D, Coon KD, Zismann VL, Beach T, Leung D, Bryden L, Halperin RF, Marlowe L, Kaleem M, Huentelman MJ, Joshipura K, Walker D, Heward CB, Ravid R, Rogers J, Papassotiropoulos A, Hardy J, Reiman EM, Stephan DA. Webster JA, et al. Among authors: coon kd. Neurodegener Dis. 2008;5(2):60-4. doi: 10.1159/000110789. Epub 2007 Nov 1. Neurodegener Dis. 2008. PMID: 17975299 Free article.
Evidence for an association between KIBRA and late-onset Alzheimer's disease.
Corneveaux JJ, Liang WS, Reiman EM, Webster JA, Myers AJ, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Craig DW, Coon KD, Dunckley T, Bandy D, Lee W, Chen K, Beach TG, Mastroeni D, Grover A, Ravid R, Sando SB, Aasly JO, Heun R, Jessen F, Kölsch H, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Papassotiropoulos A, Stephan DA, Huentelman MJ. Corneveaux JJ, et al. Among authors: coon kd. Neurobiol Aging. 2010 Jun;31(6):901-9. doi: 10.1016/j.neurobiolaging.2008.07.014. Epub 2008 Sep 13. Neurobiol Aging. 2010. PMID: 18789830 Free PMC article.
Genetic control of human brain transcript expression in Alzheimer disease.
Webster JA, Gibbs JR, Clarke J, Ray M, Zhang W, Holmans P, Rohrer K, Zhao A, Marlowe L, Kaleem M, McCorquodale DS 3rd, Cuello C, Leung D, Bryden L, Nath P, Zismann VL, Joshipura K, Huentelman MJ, Hu-Lince D, Coon KD, Craig DW, Pearson JV; NACC-Neuropathology Group; Heward CB, Reiman EM, Stephan D, Hardy J, Myers AJ. Webster JA, et al. Among authors: coon kd. Am J Hum Genet. 2009 Apr;84(4):445-58. doi: 10.1016/j.ajhg.2009.03.011. Am J Hum Genet. 2009. PMID: 19361613 Free PMC article.
Gene expression correlates of neurofibrillary tangles in Alzheimer's disease.
Dunckley T, Beach TG, Ramsey KE, Grover A, Mastroeni D, Walker DG, LaFleur BJ, Coon KD, Brown KM, Caselli R, Kukull W, Higdon R, McKeel D, Morris JC, Hulette C, Schmechel D, Reiman EM, Rogers J, Stephan DA. Dunckley T, et al. Among authors: coon kd. Neurobiol Aging. 2006 Oct;27(10):1359-71. doi: 10.1016/j.neurobiolaging.2005.08.013. Epub 2005 Oct 19. Neurobiol Aging. 2006. PMID: 16242812 Free PMC article. Clinical Trial.
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