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Mitochondrial GTP regulates glucose-stimulated insulin secretion.
Kibbey RG, Pongratz RL, Romanelli AJ, Wollheim CB, Cline GW, Shulman GI. Kibbey RG, et al. Among authors: wollheim cb. Cell Metab. 2007 Apr;5(4):253-64. doi: 10.1016/j.cmet.2007.02.008. Cell Metab. 2007. PMID: 17403370 Free PMC article.
Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.
Pongratz RL, Kibbey RG, Kirkpatrick CL, Zhao X, Pontoglio M, Yaniv M, Wollheim CB, Shulman GI, Cline GW. Pongratz RL, et al. Among authors: wollheim cb. J Biol Chem. 2009 Jun 19;284(25):16808-16821. doi: 10.1074/jbc.M807723200. Epub 2009 Apr 17. J Biol Chem. 2009. PMID: 19376774 Free PMC article.
Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.
Mahdi T, Hänzelmann S, Salehi A, Muhammed SJ, Reinbothe TM, Tang Y, Axelsson AS, Zhou Y, Jing X, Almgren P, Krus U, Taneera J, Blom AM, Lyssenko V, Esguerra JL, Hansson O, Eliasson L, Derry J, Zhang E, Wollheim CB, Groop L, Renström E, Rosengren AH. Mahdi T, et al. Among authors: wollheim cb. Cell Metab. 2012 Nov 7;16(5):625-33. doi: 10.1016/j.cmet.2012.10.009. Cell Metab. 2012. PMID: 23140642 Free article.
Mitochondrial matrix calcium is an activating signal for hormone secretion.
Wiederkehr A, Szanda G, Akhmedov D, Mataki C, Heizmann CW, Schoonjans K, Pozzan T, Spät A, Wollheim CB. Wiederkehr A, et al. Among authors: wollheim cb. Cell Metab. 2011 May 4;13(5):601-11. doi: 10.1016/j.cmet.2011.03.015. Cell Metab. 2011. PMID: 21531342 Free article.
366 results