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Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability--evidence of E2F-1 transcriptional control over hCdt1.
Karakaidos P, Taraviras S, Vassiliou LV, Zacharatos P, Kastrinakis NG, Kougiou D, Kouloukoussa M, Nishitani H, Papavassiliou AG, Lygerou Z, Gorgoulis VG. Karakaidos P, et al. Among authors: gorgoulis vg. Am J Pathol. 2004 Oct;165(4):1351-65. doi: 10.1016/S0002-9440(10)63393-7. Am J Pathol. 2004. PMID: 15466399 Free PMC article.
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints.
Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, Vassiliou LV, Kolettas E, Niforou K, Zoumpourlis VC, Takaoka M, Nakagawa H, Tort F, Fugger K, Johansson F, Sehested M, Andersen CL, Dyrskjot L, Ørntoft T, Lukas J, Kittas C, Helleday T, Halazonetis TD, Bartek J, Gorgoulis VG. Bartkova J, et al. Among authors: gorgoulis vg. Nature. 2006 Nov 30;444(7119):633-7. doi: 10.1038/nature05268. Nature. 2006. PMID: 17136093
349 results