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The phosphoinositide 3-kinase/Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27(Kip1) and control of cyclin D1 expression.
Cappellini A, Tabellini G, Zweyer M, Bortul R, Tazzari PL, Billi AM, Falà F, Cocco L, Martelli AM. Cappellini A, et al. Among authors: bortul r. Leukemia. 2003 Nov;17(11):2157-67. doi: 10.1038/sj.leu.2403111. Leukemia. 2003. PMID: 12931221
AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications.
Grimaldi C, Chiarini F, Tabellini G, Ricci F, Tazzari PL, Battistelli M, Falcieri E, Bortul R, Melchionda F, Iacobucci I, Pagliaro P, Martinelli G, Pession A, Barata JT, McCubrey JA, Martelli AM. Grimaldi C, et al. Among authors: bortul r. Leukemia. 2012 Jan;26(1):91-100. doi: 10.1038/leu.2011.269. Epub 2011 Oct 4. Leukemia. 2012. PMID: 21968881
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