Leman LJ - Search Results

1

Functional and mechanistic analyses of biomimetic aminoacyl transfer reactions in de novo designed coiled coil peptides via rational active site engineering.

Leman LJ, Weinberger DA, Huang ZZ, Wilcoxen KM, Ghadiri MR. Leman LJ, et al. J Am Chem Soc. 2007 Mar 14;129(10):2959-66. doi: 10.1021/ja068052x. Epub 2007 Feb 16. J Am Chem Soc. 2007. PMID: 17302417 Free PMC article.

2

Carbonyl sulfide-mediated prebiotic formation of peptides.

Leman L, Orgel L, Ghadiri MR. Leman L, et al. Science. 2004 Oct 8;306(5694):283-6. doi: 10.1126/science.1102722. Science. 2004. PMID: 15472077

3

Structure-based engineering of internal cavities in coiled-coil peptides.

Yadav MK, Redman JE, Leman LJ, Alvarez-Gutiérrez JM, Zhang Y, Stout CD, Ghadiri MR. Yadav MK, et al. Among authors: leman lj. Biochemistry. 2005 Jul 19;44(28):9723-32. doi: 10.1021/bi050742a. Biochemistry. 2005. PMID: 16008357 Free PMC article.

4

Amino acid dependent formation of phosphate anhydrides in water mediated by carbonyl sulfide.

Leman LJ, Orgel LE, Ghadiri MR. Leman LJ, et al. J Am Chem Soc. 2006 Jan 11;128(1):20-1. doi: 10.1021/ja056036e. J Am Chem Soc. 2006. PMID: 16390101

5

Coiled coils at the edge of configurational heterogeneity. Structural analyses of parallel and antiparallel homotetrameric coiled coils reveal configurational sensitivity to a single solvent-exposed amino acid substitution.

Yadav MK, Leman LJ, Price DJ, Brooks CL 3rd, Stout CD, Ghadiri MR. Yadav MK, et al. Among authors: leman lj. Biochemistry. 2006 Apr 11;45(14):4463-73. doi: 10.1021/bi060092q. Biochemistry. 2006. PMID: 16584182 Free PMC article.

6

Biomimetic catalysis of intermodular aminoacyl transfer.

Wilcoxen KM, Leman LJ, Weinberger DA, Huang ZZ, Ghadiri MR. Wilcoxen KM, et al. Among authors: leman lj. J Am Chem Soc. 2007 Jan 31;129(4):748-9. doi: 10.1021/ja067124h. J Am Chem Soc. 2007. PMID: 17243796 Free PMC article.

7

Biomimetic catalysis of diketopiperazine and dipeptide syntheses.

Huang ZZ, Leman LJ, Ghadiri MR. Huang ZZ, et al. Among authors: leman lj. Angew Chem Int Ed Engl. 2008;47(9):1758-61. doi: 10.1002/anie.200704266. Angew Chem Int Ed Engl. 2008. PMID: 18213666 Free PMC article.

8

Self-assembling sequence-adaptive peptide nucleic acids.

Ura Y, Beierle JM, Leman LJ, Orgel LE, Ghadiri MR. Ura Y, et al. Among authors: leman lj. Science. 2009 Jul 3;325(5936):73-7. doi: 10.1126/science.1174577. Epub 2009 Jun 11. Science. 2009. PMID: 19520909

9

Dynamic polythioesters via ring-opening polymerization of 1,4-thiazine-2,5-diones.

Ura Y, Al-Sayah M, Montenegro J, Beierle JM, Leman LJ, Ghadiri MR. Ura Y, et al. Among authors: leman lj. Org Biomol Chem. 2009 Jul 21;7(14):2878-84. doi: 10.1039/b903612a. Epub 2009 Jun 8. Org Biomol Chem. 2009. PMID: 19582297

10

Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ΔF508-CFTR.

Hutt DM, Olsen CA, Vickers CJ, Herman D, Chalfant M, Montero A, Leman LJ, Burkle R, Maryanoff BE, Balch WE, Ghadiri MR. Hutt DM, et al. Among authors: leman lj. ACS Med Chem Lett. 2011 Jul 21;2(9):703-707. doi: 10.1021/ml200136e. ACS Med Chem Lett. 2011. PMID: 21984958 Free PMC article.

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