Aakre ME - Search Results

1

Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression.

Ijichi H, Chytil A, Gorska AE, Aakre ME, Fujitani Y, Fujitani S, Wright CV, Moses HL. Ijichi H, et al. Among authors: aakre me. Genes Dev. 2006 Nov 15;20(22):3147-60. doi: 10.1101/gad.1475506. Genes Dev. 2006. PMID: 17114585 Free PMC article.

2

Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis.

Forrester E, Chytil A, Bierie B, Aakre M, Gorska AE, Sharif-Afshar AR, Muller WJ, Moses HL. Forrester E, et al. Cancer Res. 2005 Mar 15;65(6):2296-302. doi: 10.1158/0008-5472.CAN-04-3272. Cancer Res. 2005. PMID: 15781643

3

Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis.

Yang L, Huang J, Ren X, Gorska AE, Chytil A, Aakre M, Carbone DP, Matrisian LM, Richmond A, Lin PC, Moses HL. Yang L, et al. Cancer Cell. 2008 Jan;13(1):23-35. doi: 10.1016/j.ccr.2007.12.004. Cancer Cell. 2008. PMID: 18167337 Free PMC article.

4

Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment.

Bierie B, Stover DG, Abel TW, Chytil A, Gorska AE, Aakre M, Forrester E, Yang L, Wagner KU, Moses HL. Bierie B, et al. Cancer Res. 2008 Mar 15;68(6):1809-19. doi: 10.1158/0008-5472.CAN-07-5597. Cancer Res. 2008. PMID: 18339861

5

Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer.

Bierie B, Chung CH, Parker JS, Stover DG, Cheng N, Chytil A, Aakre M, Shyr Y, Moses HL. Bierie B, et al. J Clin Invest. 2009 Jun;119(6):1571-82. doi: 10.1172/JCI37480. Epub 2009 May 18. J Clin Invest. 2009. PMID: 19451693 Free PMC article.

6

TGF-β receptor II loss promotes mammary carcinoma progression by Th17 dependent mechanisms.

Novitskiy SV, Pickup MW, Gorska AE, Owens P, Chytil A, Aakre M, Wu H, Shyr Y, Moses HL. Novitskiy SV, et al. Cancer Discov. 2011 Oct;1(5):430-41. doi: 10.1158/2159-8290.CD-11-0100. Cancer Discov. 2011. PMID: 22408746 Free PMC article.

7

Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-β-deficient mouse mammary carcinomas.

Pickup MW, Laklai H, Acerbi I, Owens P, Gorska AE, Chytil A, Aakre M, Weaver VM, Moses HL. Pickup MW, et al. Cancer Res. 2013 Sep 1;73(17):5336-46. doi: 10.1158/0008-5472.CAN-13-0012. Epub 2013 Jul 15. Cancer Res. 2013. PMID: 23856251 Free PMC article.

8

Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells.

Law BK, Chytil A, Dumont N, Hamilton EG, Waltner-Law ME, Aakre ME, Covington C, Moses HL. Law BK, et al. Among authors: aakre me. Mol Cell Biol. 2002 Dec;22(23):8184-98. doi: 10.1128/MCB.22.23.8184-8198.2002. Mol Cell Biol. 2002. PMID: 12417722 Free PMC article.

9

Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-beta receptor exhibit impaired mammary development and enhanced mammary tumor formation.

Gorska AE, Jensen RA, Shyr Y, Aakre ME, Bhowmick NA, Moses HL. Gorska AE, et al. Among authors: aakre me. Am J Pathol. 2003 Oct;163(4):1539-49. doi: 10.1016/s0002-9440(10)63510-9. Am J Pathol. 2003. PMID: 14507660 Free PMC article.

10

TGF-beta-induced RhoA and p160ROCK activation is involved in the inhibition of Cdc25A with resultant cell-cycle arrest.

Bhowmick NA, Ghiassi M, Aakre M, Brown K, Singh V, Moses HL. Bhowmick NA, et al. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15548-53. doi: 10.1073/pnas.2536483100. Epub 2003 Dec 1. Proc Natl Acad Sci U S A. 2003. PMID: 14657354 Free PMC article.

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