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51 results

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Page 1
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds.
Engel M, Hindie V, Lopez-Garcia LA, Stroba A, Schaeffer F, Adrian I, Imig J, Idrissova L, Nastainczyk W, Zeuzem S, Alzari PM, Hartmann RW, Piiper A, Biondi RM. Engel M, et al. Among authors: schaeffer f. EMBO J. 2006 Nov 29;25(23):5469-80. doi: 10.1038/sj.emboj.7601416. Epub 2006 Nov 16. EMBO J. 2006. PMID: 17110931 Free PMC article.
3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds.
Stroba A, Schaeffer F, Hindie V, Lopez-Garcia L, Adrian I, Fröhner W, Hartmann RW, Biondi RM, Engel M. Stroba A, et al. Among authors: schaeffer f. J Med Chem. 2009 Aug 13;52(15):4683-93. doi: 10.1021/jm9001499. J Med Chem. 2009. PMID: 19606904
Structural basis of lipid biosynthesis regulation in Gram-positive bacteria.
Schujman GE, Guerin M, Buschiazzo A, Schaeffer F, Llarrull LI, Reh G, Vila AJ, Alzari PM, de Mendoza D. Schujman GE, et al. Among authors: schaeffer f. EMBO J. 2006 Sep 6;25(17):4074-83. doi: 10.1038/sj.emboj.7601284. Epub 2006 Aug 24. EMBO J. 2006. PMID: 16932747 Free PMC article.
A novel role of malonyl-ACP in lipid homeostasis.
Martinez MA, Zaballa ME, Schaeffer F, Bellinzoni M, Albanesi D, Schujman GE, Vila AJ, Alzari PM, de Mendoza D. Martinez MA, et al. Among authors: schaeffer f. Biochemistry. 2010 Apr 13;49(14):3161-7. doi: 10.1021/bi100136n. Biochemistry. 2010. PMID: 20201588
51 results