Hartmann RW - Search Results

1

Allosteric activation of the protein kinase PDK1 with low molecular weight compounds.

Engel M, Hindie V, Lopez-Garcia LA, Stroba A, Schaeffer F, Adrian I, Imig J, Idrissova L, Nastainczyk W, Zeuzem S, Alzari PM, Hartmann RW, Piiper A, Biondi RM. Engel M, et al. Among authors: hartmann rw. EMBO J. 2006 Nov 29;25(23):5469-80. doi: 10.1038/sj.emboj.7601416. Epub 2006 Nov 16. EMBO J. 2006. PMID: 17110931 Free PMC article.

2

3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds.

Stroba A, Schaeffer F, Hindie V, Lopez-Garcia L, Adrian I, Fröhner W, Hartmann RW, Biondi RM, Engel M. Stroba A, et al. Among authors: hartmann rw. J Med Chem. 2009 Aug 13;52(15):4683-93. doi: 10.1021/jm9001499. J Med Chem. 2009. PMID: 19606904

3

Design of novel β-carboline derivatives with pendant 5-bromothienyl and their evaluation as phosphodiesterase-5 inhibitors.

El-Gamil DS, Ahmed NS, Gary BD, Piazza GA, Engel M, Hartmann RW, Abadi AH. El-Gamil DS, et al. Among authors: hartmann rw. Arch Pharm (Weinheim). 2013 Jan;346(1):23-33. doi: 10.1002/ardp.201200334. Arch Pharm (Weinheim). 2013. PMID: 23307609 Free PMC article.

4

6-Aryl and heterocycle quinazoline derivatives as potent EGFR inhibitors with improved activity toward gefitinib-sensitive and -resistant tumor cell lines.

Hamed MM, Abou El Ella DA, Keeton AB, Piazza GA, Abadi AH, Hartmann RW, Engel M. Hamed MM, et al. Among authors: hartmann rw. ChemMedChem. 2013 Sep;8(9):1495-504. doi: 10.1002/cmdc.201300147. Epub 2013 Jul 11. ChemMedChem. 2013. PMID: 23847159

5

Highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to reduce risks of cardiovascular diseases.

Pinto-Bazurco Mendieta MA, Hu Q, Engel M, Hartmann RW. Pinto-Bazurco Mendieta MA, et al. Among authors: hartmann rw. J Med Chem. 2013 Aug 8;56(15):6101-7. doi: 10.1021/jm400484p. Epub 2013 Jul 29. J Med Chem. 2013. PMID: 23859149

6

Trisubstituted and tetrasubstituted pyrazolines as a novel class of cell-growth inhibitors in tumor cells with wild type p53.

Abdel-Halim M, Keeton AB, Gurpinar E, Gary BD, Vogel SM, Engel M, Piazza GA, Boeckler FM, Hartmann RW, Abadi AH. Abdel-Halim M, et al. Among authors: hartmann rw. Bioorg Med Chem. 2013 Dec 1;21(23):7343-56. doi: 10.1016/j.bmc.2013.09.055. Epub 2013 Oct 1. Bioorg Med Chem. 2013. PMID: 24139845

7

Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitors.

Schmitt C, Kail D, Mariano M, Empting M, Weber N, Paul T, Hartmann RW, Engel M. Schmitt C, et al. Among authors: hartmann rw. PLoS One. 2014 Mar 27;9(3):e87851. doi: 10.1371/journal.pone.0087851. eCollection 2014. PLoS One. 2014. PMID: 24676346 Free PMC article.

8

6-Hydroxybenzothiophene ketones: potent inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) owing to favorable molecule geometry and conformational preorganization.

Miralinaghi P, Schmitt C, Hartmann RW, Frotscher M, Engel M. Miralinaghi P, et al. Among authors: hartmann rw. ChemMedChem. 2014 Oct;9(10):2294-308. doi: 10.1002/cmdc.201402050. Epub 2014 Jul 14. ChemMedChem. 2014. PMID: 25044709

9

Discovery and optimization of 1,3,5-trisubstituted pyrazolines as potent and highly selective allosteric inhibitors of protein kinase C-ζ.

Abdel-Halim M, Diesel B, Kiemer AK, Abadi AH, Hartmann RW, Engel M. Abdel-Halim M, et al. Among authors: hartmann rw. J Med Chem. 2014 Aug 14;57(15):6513-30. doi: 10.1021/jm500521n. Epub 2014 Jul 24. J Med Chem. 2014. PMID: 25058929

10

Hydroxybenzothiophene Ketones Are Efficient Pre-mRNA Splicing Modulators Due to Dual Inhibition of Dyrk1A and Clk1/4.

Schmitt C, Miralinaghi P, Mariano M, Hartmann RW, Engel M. Schmitt C, et al. Among authors: hartmann rw. ACS Med Chem Lett. 2014 Jul 14;5(9):963-7. doi: 10.1021/ml500059y. eCollection 2014 Sep 11. ACS Med Chem Lett. 2014. PMID: 25221649 Free PMC article.

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