Vandenberg CJ - Search Results

1

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

van Delft MF, Wei AH, Mason KD, Vandenberg CJ, Chen L, Czabotar PE, Willis SN, Scott CL, Day CL, Cory S, Adams JM, Roberts AW, Huang DC. van Delft MF, et al. Among authors: vandenberg cj. Cancer Cell. 2006 Nov;10(5):389-99. doi: 10.1016/j.ccr.2006.08.027. Cancer Cell. 2006. PMID: 17097561 Free PMC article.

2

In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas.

Mason KD, Vandenberg CJ, Scott CL, Wei AH, Cory S, Huang DC, Roberts AW. Mason KD, et al. Among authors: vandenberg cj. Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17961-6. doi: 10.1073/pnas.0809957105. Epub 2008 Nov 11. Proc Natl Acad Sci U S A. 2008. PMID: 19004807 Free PMC article.

3

Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance.

Campbell KJ, Bath ML, Turner ML, Vandenberg CJ, Bouillet P, Metcalf D, Scott CL, Cory S. Campbell KJ, et al. Among authors: vandenberg cj. Blood. 2010 Oct 28;116(17):3197-207. doi: 10.1182/blood-2010-04-281071. Epub 2010 Jul 14. Blood. 2010. PMID: 20631380 Free PMC article.

4

Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death.

Michalak EM, Vandenberg CJ, Delbridge AR, Wu L, Scott CL, Adams JM, Strasser A. Michalak EM, et al. Among authors: vandenberg cj. Genes Dev. 2010 Aug 1;24(15):1608-13. doi: 10.1101/gad.1940110. Genes Dev. 2010. PMID: 20679396 Free PMC article.

5

Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim.

Happo L, Cragg MS, Phipson B, Haga JM, Jansen ES, Herold MJ, Dewson G, Michalak EM, Vandenberg CJ, Smyth GK, Strasser A, Cory S, Scott CL. Happo L, et al. Among authors: vandenberg cj. Blood. 2010 Dec 9;116(24):5256-67. doi: 10.1182/blood-2010-04-280818. Epub 2010 Sep 9. Blood. 2010. PMID: 20829369 Free PMC article.

6

Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells.

Mérino D, Khaw SL, Glaser SP, Anderson DJ, Belmont LD, Wong C, Yue P, Robati M, Phipson B, Fairlie WD, Lee EF, Campbell KJ, Vandenberg CJ, Cory S, Roberts AW, Ludlam MJ, Huang DC, Bouillet P. Mérino D, et al. Among authors: vandenberg cj. Blood. 2012 Jun 14;119(24):5807-16. doi: 10.1182/blood-2011-12-400929. Epub 2012 Apr 26. Blood. 2012. PMID: 22538851 Free PMC article.

7

DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa.

Kerr JB, Hutt KJ, Michalak EM, Cook M, Vandenberg CJ, Liew SH, Bouillet P, Mills A, Scott CL, Findlay JK, Strasser A. Kerr JB, et al. Among authors: vandenberg cj. Mol Cell. 2012 Nov 9;48(3):343-52. doi: 10.1016/j.molcel.2012.08.017. Epub 2012 Sep 20. Mol Cell. 2012. PMID: 23000175 Free PMC article.

8

ABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia.

Vandenberg CJ, Cory S. Vandenberg CJ, et al. Blood. 2013 Mar 21;121(12):2285-8. doi: 10.1182/blood-2013-01-475855. Epub 2013 Jan 22. Blood. 2013. PMID: 23341542 Free PMC article.

9

Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice.

Vandenberg CJ, Josefsson EC, Campbell KJ, James C, Lawlor KE, Kile BT, Cory S. Vandenberg CJ, et al. Cell Death Differ. 2014 May;21(5):676-84. doi: 10.1038/cdd.2013.201. Epub 2014 Jan 24. Cell Death Differ. 2014. PMID: 24464220 Free PMC article.

10

Plasmacytomagenesis in Eμ-v-abl transgenic mice is accelerated when apoptosis is restrained.

Vandenberg CJ, Waring P, Strasser A, Cory S. Vandenberg CJ, et al. Blood. 2014 Aug 14;124(7):1099-109. doi: 10.1182/blood-2014-04-570770. Epub 2014 Jul 1. Blood. 2014. PMID: 24986687 Free PMC article.

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