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Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases.
Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW, Kolski-Andreaco A, Wei E, Grino A, Counts DR, Wang PH, LeeHealey CJ, S Andrews B, Sankaranarayanan A, Homerick D, Roeck WW, Tehranzadeh J, Stanhope KL, Zimin P, Havel PJ, Griffey S, Knaus HG, Nepom GT, Gutman GA, Calabresi PA, Chandy KG. Beeton C, et al. Among authors: s andrews b, griffey s. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17414-9. doi: 10.1073/pnas.0605136103. Epub 2006 Nov 6. Proc Natl Acad Sci U S A. 2006. PMID: 17088564 Free PMC article.
Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance.
Upadhyay SK, Eckel-Mahan KL, Mirbolooki MR, Tjong I, Griffey SM, Schmunk G, Koehne A, Halbout B, Iadonato S, Pedersen B, Borrelli E, Wang PH, Mukherjee J, Sassone-Corsi P, Chandy KG. Upadhyay SK, et al. Among authors: griffey sm. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):E2239-48. doi: 10.1073/pnas.1221206110. Epub 2013 May 31. Proc Natl Acad Sci U S A. 2013. PMID: 23729813 Free PMC article.
Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.
Bergo MO, Gavino B, Ross J, Schmidt WK, Hong C, Kendall LV, Mohr A, Meta M, Genant H, Jiang Y, Wisner ER, Van Bruggen N, Carano RA, Michaelis S, Griffey SM, Young SG. Bergo MO, et al. Among authors: griffey sm. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13049-54. doi: 10.1073/pnas.192460799. Epub 2002 Sep 16. Proc Natl Acad Sci U S A. 2002. PMID: 12235369 Free PMC article.
The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice.
López-Domínguez JA, Ramsey JJ, Tran D, Imai DM, Koehne A, Laing ST, Griffey SM, Kim K, Taylor SL, Hagopian K, Villalba JM, López-Lluch G, Navas P, McDonald RB. López-Domínguez JA, et al. J Gerontol A Biol Sci Med Sci. 2015 Oct;70(10):1181-8. doi: 10.1093/gerona/glu177. Epub 2014 Oct 13. J Gerontol A Biol Sci Med Sci. 2015. PMID: 25313149 Free PMC article.
The influence of Shc proteins on life span in mice.
Ramsey JJ, Tran D, Giorgio M, Griffey SM, Koehne A, Laing ST, Taylor SL, Kim K, Cortopassi GA, Lloyd KC, Hagopian K, Tomilov AA, Migliaccio E, Pelicci PG, McDonald RB. Ramsey JJ, et al. J Gerontol A Biol Sci Med Sci. 2014 Oct;69(10):1177-85. doi: 10.1093/gerona/glt198. Epub 2013 Dec 14. J Gerontol A Biol Sci Med Sci. 2014. PMID: 24336818 Free PMC article.
182 results