Sun S - Search Results

1

Biochemical basis of glucokinase activation and the regulation by glucokinase regulatory protein in naturally occurring mutations.

Heredia VV, Carlson TJ, Garcia E, Sun S. Heredia VV, et al. Among authors: sun s. J Biol Chem. 2006 Dec 29;281(52):40201-7. doi: 10.1074/jbc.M607987200. Epub 2006 Nov 2. J Biol Chem. 2006. PMID: 17082186 Free article.

2

Glucose-induced conformational changes in glucokinase mediate allosteric regulation: transient kinetic analysis.

Heredia VV, Thomson J, Nettleton D, Sun S. Heredia VV, et al. Among authors: sun s. Biochemistry. 2006 Jun 20;45(24):7553-62. doi: 10.1021/bi060253q. Biochemistry. 2006. PMID: 16768451

3

Assay development and data analysis of receptor-ligand binding based on scintillation proximity assay.

Sun S, Almaden J, Carlson TJ, Barker J, Gehring MR. Sun S, et al. Metab Eng. 2005 Jan;7(1):38-44. doi: 10.1016/j.ymben.2004.05.004. Metab Eng. 2005. PMID: 15721809

4

Pyridine-3-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.

Humphries PS, Bailey S, Almaden JV, Barnum SJ, Carlson TJ, Christie LC, Do QQ, Fraser JD, Hess M, Kellum J, Kim YH, McClellan GA, Ogilvie KM, Simmons BH, Skalitzky D, Sun S, Wilhite D, Zehnder LR. Humphries PS, et al. Among authors: sun s. Bioorg Med Chem Lett. 2006 Dec 1;16(23):6120-3. doi: 10.1016/j.bmcl.2006.08.110. Epub 2006 Sep 14. Bioorg Med Chem Lett. 2006. PMID: 16973358

5

Pyridine-2-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.

Humphries PS, Almaden JV, Barnum SJ, Carlson TJ, Do QQ, Fraser JD, Hess M, Kim YH, Ogilvie KM, Sun S. Humphries PS, et al. Among authors: sun s. Bioorg Med Chem Lett. 2006 Dec 1;16(23):6116-9. doi: 10.1016/j.bmcl.2006.08.105. Epub 2006 Sep 18. Bioorg Med Chem Lett. 2006. PMID: 16979341

6

Glucose modulation of glucokinase activation by small molecules.

Ralph EC, Thomson J, Almaden J, Sun S. Ralph EC, et al. Among authors: sun s. Biochemistry. 2008 Apr 29;47(17):5028-36. doi: 10.1021/bi702516y. Epub 2008 Mar 28. Biochemistry. 2008. PMID: 18370405

7

Biochemical characterization of MODY2 glucokinase variants V62M and G72R reveals reduced enzymatic activities relative to wild type.

Ralph EC, Sun S. Ralph EC, et al. Among authors: sun s. Biochemistry. 2009 Mar 24;48(11):2514-21. doi: 10.1021/bi900020n. Biochemistry. 2009. PMID: 19187021

8

Steady-state kinetic and inhibition studies of the mammalian target of rapamycin (mTOR) kinase domain and mTOR complexes.

Tao Z, Barker J, Shi SD, Gehring M, Sun S. Tao Z, et al. Among authors: sun s. Biochemistry. 2010 Oct 5;49(39):8488-98. doi: 10.1021/bi100673c. Epub 2010 Sep 8. Biochemistry. 2010. PMID: 20804212

9

Preclinical PK/PD modeling and human efficacious dose projection for a glucokinase activator in the treatment of diabetes.

Zager MG, Kozminski K, Pascual B, Ogilvie KM, Sun S. Zager MG, et al. Among authors: sun s. J Pharmacokinet Pharmacodyn. 2014 Apr;41(2):127-39. doi: 10.1007/s10928-014-9351-7. Epub 2014 Feb 28. J Pharmacokinet Pharmacodyn. 2014. PMID: 24578187

10

Structure-based design, SAR analysis and antitumor activity of PI3K/mTOR dual inhibitors from 4-methylpyridopyrimidinone series.

Cheng H, Hoffman JE, Le PT, Pairish M, Kania R, Farrell W, Bagrodia S, Yuan J, Sun S, Zhang E, Xiang C, Dalvie D, Rahavendran SV. Cheng H, et al. Among authors: sun s. Bioorg Med Chem Lett. 2013 May 1;23(9):2787-92. doi: 10.1016/j.bmcl.2013.02.020. Epub 2013 Feb 13. Bioorg Med Chem Lett. 2013. PMID: 23506825

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