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Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin.
Cruz MC, Del Poeta M, Wang P, Wenger R, Zenke G, Quesniaux VF, Movva NR, Perfect JR, Cardenas ME, Heitman J. Cruz MC, et al. Among authors: movva nr. Antimicrob Agents Chemother. 2000 Jan;44(1):143-9. doi: 10.1128/AAC.44.1.143-149.2000. Antimicrob Agents Chemother. 2000. PMID: 10602736 Free PMC article.
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