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Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites.
Glenn MP, Chang SY, Hornéy C, Rivas K, Yokoyama K, Pusateri EE, Fletcher S, Cummings CG, Buckner FS, Pendyala PR, Chakrabarti D, Sebti SM, Gelb M, Van Voorhis WC, Hamilton AD. Glenn MP, et al. Among authors: gelb m. J Med Chem. 2006 Sep 21;49(19):5710-27. doi: 10.1021/jm060081v. J Med Chem. 2006. PMID: 16970397 Free PMC article.
Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites.
Glenn MP, Chang SY, Hucke O, Verlinde CL, Rivas K, Hornéy C, Yokoyama K, Buckner FS, Pendyala PR, Chakrabarti D, Gelb M, Van Voorhis WC, Sebti SM, Hamilton AD. Glenn MP, et al. Among authors: gelb m. Angew Chem Int Ed Engl. 2005 Aug 5;44(31):4903-6. doi: 10.1002/anie.200500674. Angew Chem Int Ed Engl. 2005. PMID: 16007716 No abstract available.
Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.
Nallan L, Bauer KD, Bendale P, Rivas K, Yokoyama K, Hornéy CP, Pendyala PR, Floyd D, Lombardo LJ, Williams DK, Hamilton A, Sebti S, Windsor WT, Weber PC, Buckner FS, Chakrabarti D, Gelb MH, Van Voorhis WC. Nallan L, et al. J Med Chem. 2005 Jun 2;48(11):3704-13. doi: 10.1021/jm0491039. J Med Chem. 2005. PMID: 15916422
Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials.
Bendale P, Olepu S, Suryadevara PK, Bulbule V, Rivas K, Nallan L, Smart B, Yokoyama K, Ankala S, Pendyala PR, Floyd D, Lombardo LJ, Williams DK, Buckner FS, Chakrabarti D, Verlinde CL, Van Voorhis WC, Gelb MH. Bendale P, et al. Among authors: gelb mh. J Med Chem. 2007 Sep 20;50(19):4585-605. doi: 10.1021/jm0703340. Epub 2007 Aug 28. J Med Chem. 2007. PMID: 17722901 Free PMC article.
Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation.
Fletcher S, Cummings CG, Rivas K, Katt WP, Hornéy C, Buckner FS, Chakrabarti D, Sebti SM, Gelb MH, Van Voorhis WC, Hamilton AD. Fletcher S, et al. Among authors: gelb mh. J Med Chem. 2008 Sep 11;51(17):5176-97. doi: 10.1021/jm800113p. Epub 2008 Aug 8. J Med Chem. 2008. PMID: 18686940 Free PMC article.
515 results