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AVE0118, blocker of the transient outward current (I(to)) and ultrarapid delayed rectifier current (I(Kur)), fully restores atrial contractility after cardioversion of atrial fibrillation in the goat.
de Haan S, Greiser M, Harks E, Blaauw Y, van Hunnik A, Verheule S, Allessie M, Schotten U. de Haan S, et al. Among authors: harks e. Circulation. 2006 Sep 19;114(12):1234-42. doi: 10.1161/CIRCULATIONAHA.106.630905. Epub 2006 Aug 28. Circulation. 2006. PMID: 16940189
Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation.
Greiser M, Neuberger HR, Harks E, El-Armouche A, Boknik P, de Haan S, Verheyen F, Verheule S, Schmitz W, Ravens U, Nattel S, Allessie MA, Dobrev D, Schotten U. Greiser M, et al. Among authors: harks e. J Mol Cell Cardiol. 2009 Mar;46(3):385-94. doi: 10.1016/j.yjmcc.2008.11.012. Epub 2008 Nov 27. J Mol Cell Cardiol. 2009. PMID: 19100271
Tachycardia-induced silencing of subcellular Ca2+ signaling in atrial myocytes.
Greiser M, Kerfant BG, Williams GS, Voigt N, Harks E, Dibb KM, Giese A, Meszaros J, Verheule S, Ravens U, Allessie MA, Gammie JS, van der Velden J, Lederer WJ, Dobrev D, Schotten U. Greiser M, et al. Among authors: harks e. J Clin Invest. 2014 Nov;124(11):4759-72. doi: 10.1172/JCI70102. Epub 2014 Oct 20. J Clin Invest. 2014. PMID: 25329692 Free PMC article.
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