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Chromosomal translocations fusing the BCL6 gene to different partner loci are recurrent in primary central nervous system lymphoma and may be associated with aberrant somatic hypermutation or defective class switch recombination.
Schwindt H, Akasaka T, Zühlke-Jenisch R, Hans V, Schaller C, Klapper W, Dyer MJ, Siebert R, Deckert M. Schwindt H, et al. Among authors: akasaka t. J Neuropathol Exp Neurol. 2006 Aug;65(8):776-82. doi: 10.1097/01.jnen.0000229988.48042.ae. J Neuropathol Exp Neurol. 2006. PMID: 16896311
Molecular characterization of BCL6 breakpoints in primary diffuse large B-cell lymphomas of the central nervous system identifies GAPD as novel translocation partner.
Montesinos-Rongen M, Akasaka T, Zühlke-Jenisch R, Schaller C, Van Roost D, Wiestler OD, Siebert R, Deckert M. Montesinos-Rongen M, et al. Among authors: akasaka t. Brain Pathol. 2003 Oct;13(4):534-8. doi: 10.1111/j.1750-3639.2003.tb00483.x. Brain Pathol. 2003. PMID: 14655758 Free PMC article.
Deregulation of the telomerase reverse transcriptase (TERT) gene by chromosomal translocations in B-cell malignancies.
Nagel I, Szczepanowski M, Martín-Subero JI, Harder L, Akasaka T, Ammerpohl O, Callet-Bauchu E, Gascoyne RD, Gesk S, Horsman D, Klapper W, Majid A, Martinez-Climent JA, Stilgenbauer S, Tönnies H, Dyer MJ, Siebert R. Nagel I, et al. Among authors: akasaka t. Blood. 2010 Aug 26;116(8):1317-20. doi: 10.1182/blood-2009-09-240440. Epub 2010 May 11. Blood. 2010. PMID: 20460502 Free article.
Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL).
Akasaka T, Balasas T, Russell LJ, Sugimoto KJ, Majid A, Walewska R, Karran EL, Brown DG, Cain K, Harder L, Gesk S, Martin-Subero JI, Atherton MG, Brüggemann M, Calasanz MJ, Davies T, Haas OA, Hagemeijer A, Kempski H, Lessard M, Lillington DM, Moore S, Nguyen-Khac F, Radford-Weiss I, Schoch C, Struski S, Talley P, Welham MJ, Worley H, Strefford JC, Harrison CJ, Siebert R, Dyer MJ. Akasaka T, et al. Blood. 2007 Apr 15;109(8):3451-61. doi: 10.1182/blood-2006-08-041012. Epub 2006 Dec 14. Blood. 2007. PMID: 17170124 Free article. Clinical Trial.
t(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL).
Russell LJ, Akasaka T, Majid A, Sugimoto KJ, Loraine Karran E, Nagel I, Harder L, Claviez A, Gesk S, Moorman AV, Ross F, Mazzullo H, Strefford JC, Siebert R, Dyer MJ, Harrison CJ. Russell LJ, et al. Among authors: akasaka t. Blood. 2008 Jan 1;111(1):387-91. doi: 10.1182/blood-2007-07-092015. Epub 2007 Oct 16. Blood. 2008. PMID: 17940204 Free article.
Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol.
Cario G, Zimmermann M, Romey R, Gesk S, Vater I, Harbott J, Schrauder A, Moericke A, Izraeli S, Akasaka T, Dyer MJ, Siebert R, Schrappe M, Stanulla M. Cario G, et al. Among authors: akasaka t. Blood. 2010 Jul 1;115(26):5393-7. doi: 10.1182/blood-2009-11-256131. Epub 2010 Apr 8. Blood. 2010. PMID: 20378752 Free article.
1,401 results