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Page 1
Aza-stilbenes as potent and selective c-RAF inhibitors.
McDonald O, Lackey K, Davis-Ward R, Wood E, Samano V, Maloney P, Deanda F, Hunter R. McDonald O, et al. Among authors: samano v. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5378-83. doi: 10.1016/j.bmcl.2006.07.063. Epub 2006 Aug 4. Bioorg Med Chem Lett. 2006. PMID: 16890436
Novel, potent P2-P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors.
Barrett DG, Catalano JG, Deaton DN, Hassell AM, Long ST, Miller AB, Miller LR, Ray JA, Samano V, Shewchuk LM, Wells-Knecht KJ, Willard DH Jr, Wright LL. Barrett DG, et al. Among authors: samano v. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1735-9. doi: 10.1016/j.bmcl.2005.11.101. Epub 2006 Jan 11. Bioorg Med Chem Lett. 2006. PMID: 16376075
Synthesis of novel anilinoquinolines as c-fms inhibitors.
Smalley TL Jr, Chamberlain SD, Mills WY, Musso DL, Randhawa SA, Ray JA, Samano V, Frick L. Smalley TL Jr, et al. Among authors: samano v. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6257-60. doi: 10.1016/j.bmcl.2007.09.009. Epub 2007 Sep 7. Bioorg Med Chem Lett. 2007. PMID: 17870531
P2-P3 conformationally constrained ketoamide-based inhibitors of cathepsin K.
Barrett DG, Boncek VM, Catalano JG, Deaton DN, Hassell AM, Jurgensen CH, Long ST, McFadyen RB, Miller AB, Miller LR, Payne JA, Ray JA, Samano V, Shewchuk LM, Tavares FX, Wells-Knecht KJ, Willard DH Jr, Wright LL, Zhou HQ. Barrett DG, et al. Among authors: samano v. Bioorg Med Chem Lett. 2005 Aug 1;15(15):3540-6. doi: 10.1016/j.bmcl.2005.05.062. Bioorg Med Chem Lett. 2005. PMID: 15982880
Acyclic, orally bioavailable ketone-based cathepsin K inhibitors.
Barrett DG, Catalano JG, Deaton DN, Long ST, McFadyen RB, Miller AB, Miller LR, Samano V, Tavares FX, Wells-Knecht KJ, Wright LL, Zhou HQ. Barrett DG, et al. Among authors: samano v. Bioorg Med Chem Lett. 2007 Jan 1;17(1):22-7. doi: 10.1016/j.bmcl.2006.10.102. Epub 2006 Nov 17. Bioorg Med Chem Lett. 2007. PMID: 17157021
Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.
Maynard A, Crosby RM, Ellis B, Hamatake R, Hong Z, Johns BA, Kahler KM, Koble C, Leivers A, Leivers MR, Mathis A, Peat AJ, Pouliot JJ, Roberts CD, Samano V, Schmidt RM, Smith GK, Spaltenstein A, Stewart EL, Thommes P, Turner EM, Voitenleitner C, Walker JT, Waitt G, Weatherhead J, Weaver K, Williams S, Wright L, Xiong ZZ, Haigh D, Shotwell JB. Maynard A, et al. Among authors: samano v. J Med Chem. 2014 Mar 13;57(5):1902-13. doi: 10.1021/jm400317w. Epub 2013 May 29. J Med Chem. 2014. PMID: 23672667
DNA-Encoded Library Technology-Based Discovery, Lead Optimization, and Prodrug Strategy toward Structurally Unique Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors.
Kazmierski WM, Xia B, Miller J, De la Rosa M, Favre D, Dunham RM, Washio Y, Zhu Z, Wang F, Mebrahtu M, Deng H, Basilla J, Wang L, Evindar G, Fan L, Olszewski A, Prabhu N, Davie C, Messer JA, Samano V. Kazmierski WM, et al. Among authors: samano v. J Med Chem. 2020 Apr 9;63(7):3552-3562. doi: 10.1021/acs.jmedchem.9b01799. Epub 2020 Mar 19. J Med Chem. 2020. PMID: 32073266
Neuromuscular blocking activity and therapeutic potential of mixed-tetrahydroisoquinolinium halofumarates and halosuccinates in rhesus monkeys.
Boros EE, Samano V, Ray JA, Thompson JB, Jung DK, Kaldor I, Koble CS, Martin MT, Styles VL, Mook RA Jr, Feldman PL, Savarese JJ, Belmont MR, Bigham EC, Boswell GE, Hashim MA, Patel SS, Wisowaty JC, Bowers GD, Moseley CL, Walsh JS, Reese MJ, Rutkowske RD, Sefler AM, Spitzer TD. Boros EE, et al. Among authors: samano v. J Med Chem. 2003 Jun 5;46(12):2502-15. doi: 10.1021/jm020574+. J Med Chem. 2003. PMID: 12773054
Pyrazolopyridine antiherpetics: SAR of C2' and C7 amine substituents.
Johns BA, Gudmundsson KS, Turner EM, Allen SH, Samano VA, Ray JA, Freeman GA, Boyd FL Jr, Sexton CJ, Selleseth DW, Creech KL, Moniri KR. Johns BA, et al. Bioorg Med Chem. 2005 Apr 1;13(7):2397-411. doi: 10.1016/j.bmc.2005.01.044. Bioorg Med Chem. 2005. PMID: 15755642
28 results