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Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma.
Alsina M, Fonseca R, Wilson EF, Belle AN, Gerbino E, Price-Troska T, Overton RM, Ahmann G, Bruzek LM, Adjei AA, Kaufmann SH, Wright JJ, Sullivan D, Djulbegovic B, Cantor AB, Greipp PR, Dalton WS, Sebti SM. Alsina M, et al. Blood. 2004 May 1;103(9):3271-7. doi: 10.1182/blood-2003-08-2764. Epub 2004 Jan 15. Blood. 2004. PMID: 14726402 Free article. Clinical Trial.
Clinical significance of TP53 mutation in myeloma.
Chng WJ, Price-Troska T, Gonzalez-Paz N, Van Wier S, Jacobus S, Blood E, Henderson K, Oken M, Van Ness B, Greipp P, Rajkumar SV, Fonseca R. Chng WJ, et al. Leukemia. 2007 Mar;21(3):582-4. doi: 10.1038/sj.leu.2404524. Epub 2007 Jan 11. Leukemia. 2007. PMID: 17215851 No abstract available.
Molecular dissection of hyperdiploid multiple myeloma by gene expression profiling.
Chng WJ, Kumar S, Vanwier S, Ahmann G, Price-Troska T, Henderson K, Chung TH, Kim S, Mulligan G, Bryant B, Carpten J, Gertz M, Rajkumar SV, Lacy M, Dispenzieri A, Kyle R, Greipp P, Bergsagel PL, Fonseca R. Chng WJ, et al. Cancer Res. 2007 Apr 1;67(7):2982-9. doi: 10.1158/0008-5472.CAN-06-4046. Cancer Res. 2007. PMID: 17409404 Clinical Trial.
Diagnostic evaluation of t(4;14) in multiple myeloma and evidence for clonal evolution.
Stewart AK, Chang H, Trudel S, Anderson KC, Richardson P, Alsina M, Reece D, Young S, Sable-Hunt A, Li Z, Keats J, Van Wier S, Ahmann G, Price-Troska T, Giusti K, Bergsagel PL, Chesi M, Fonseca R. Stewart AK, et al. Leukemia. 2007 Nov;21(11):2358-9. doi: 10.1038/sj.leu.2404800. Epub 2007 Jun 14. Leukemia. 2007. PMID: 17568814 Free PMC article. No abstract available.
38 results