Lepak A - Search Results

1

In vivo fluconazole pharmacodynamics and resistance development in a previously susceptible Candida albicans population examined by microbiologic and transcriptional profiling.

Andes D, Lepak A, Nett J, Lincoln L, Marchillo K. Andes D, et al. Among authors: lepak a. Antimicrob Agents Chemother. 2006 Jul;50(7):2384-94. doi: 10.1128/AAC.01305-05. Antimicrob Agents Chemother. 2006. PMID: 16801416 Free PMC article.

2

A simple approach for estimating gene expression in Candida albicans directly from a systemic infection site.

Andes D, Lepak A, Pitula A, Marchillo K, Clark J. Andes D, et al. Among authors: lepak a. J Infect Dis. 2005 Sep 1;192(5):893-900. doi: 10.1086/432104. Epub 2005 Jul 25. J Infect Dis. 2005. PMID: 16088840

3

Time course of microbiologic outcome and gene expression in Candida albicans during and following in vitro and in vivo exposure to fluconazole.

Lepak A, Nett J, Lincoln L, Marchillo K, Andes D. Lepak A, et al. Antimicrob Agents Chemother. 2006 Apr;50(4):1311-9. doi: 10.1128/AAC.50.4.1311-1319.2006. Antimicrob Agents Chemother. 2006. PMID: 16569846 Free PMC article.

4

Impact of antimicrobial dosing regimen on evolution of drug resistance in vivo: fluconazole and Candida albicans.

Andes D, Forrest A, Lepak A, Nett J, Marchillo K, Lincoln L. Andes D, et al. Among authors: lepak a. Antimicrob Agents Chemother. 2006 Jul;50(7):2374-83. doi: 10.1128/AAC.01053-05. Antimicrob Agents Chemother. 2006. PMID: 16801415 Free PMC article.

5

Time course global gene expression analysis of an in vivo Candida biofilm.

Nett JE, Lepak AJ, Marchillo K, Andes DR. Nett JE, et al. J Infect Dis. 2009 Jul 15;200(2):307-13. doi: 10.1086/599838. J Infect Dis. 2009. PMID: 19527170 Free PMC article.

6

In vivo comparison of the pharmacodynamic targets for echinocandin drugs against Candida species.

Andes D, Diekema DJ, Pfaller MA, Bohrmuller J, Marchillo K, Lepak A. Andes D, et al. Among authors: lepak a. Antimicrob Agents Chemother. 2010 Jun;54(6):2497-506. doi: 10.1128/AAC.01584-09. Epub 2010 Apr 12. Antimicrob Agents Chemother. 2010. PMID: 20385855 Free PMC article.

7

Fungal sepsis: optimizing antifungal therapy in the critical care setting.

Lepak A, Andes D. Lepak A, et al. Crit Care Clin. 2011 Jan;27(1):123-47. doi: 10.1016/j.ccc.2010.11.001. Crit Care Clin. 2011. PMID: 21144990 Review.

8

Antifungal PK/PD considerations in fungal pulmonary infections.

Lepak AJ, Andes DR. Lepak AJ, et al. Semin Respir Crit Care Med. 2011 Dec;32(6):783-94. doi: 10.1055/s-0031-1295726. Epub 2011 Dec 13. Semin Respir Crit Care Med. 2011. PMID: 22167406 Review.

9

Editorial commentary: Antifungal therapeutic drug monitoring progress: getting it right the first time.

Andes D, Lepak A. Andes D, et al. Among authors: lepak a. Clin Infect Dis. 2012 Aug;55(3):391-3. doi: 10.1093/cid/cis446. Epub 2012 May 18. Clin Infect Dis. 2012. PMID: 22610924 No abstract available.

10

Optimizing Echinocandin dosing and susceptibility breakpoint determination via in vivo pharmacodynamic evaluation against Candida glabrata with and without fks mutations.

Lepak A, Castanheira M, Diekema D, Pfaller M, Andes D. Lepak A, et al. Antimicrob Agents Chemother. 2012 Nov;56(11):5875-82. doi: 10.1128/AAC.01102-12. Epub 2012 Sep 4. Antimicrob Agents Chemother. 2012. PMID: 22948870 Free PMC article.

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