Meyer UA - Search Results

1

Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism.

Gaedigk A, Blum M, Gaedigk R, Eichelbaum M, Meyer UA. Gaedigk A, et al. Among authors: meyer ua. Am J Hum Genet. 1991 May;48(5):943-50. Am J Hum Genet. 1991. PMID: 1673290 Free PMC article.

2

Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population.

Broly F, Gaedigk A, Heim M, Eichelbaum M, Morike K, Meyer UA. Broly F, et al. Among authors: meyer ua. DNA Cell Biol. 1991 Oct;10(8):545-58. doi: 10.1089/dna.1991.10.545. DNA Cell Biol. 1991. PMID: 1681816

3

Molecular mechanism of slow acetylation of drugs and carcinogens in humans.

Blum M, Demierre A, Grant DM, Heim M, Meyer UA. Blum M, et al. Among authors: meyer ua. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5237-41. doi: 10.1073/pnas.88.12.5237. Proc Natl Acad Sci U S A. 1991. PMID: 1675794 Free PMC article.

4

N-acetylation pharmacogenetics: a gene deletion causes absence of arylamine N-acetyltransferase in liver of slow acetylator rabbits.

Blum M, Grant DM, Demierre A, Meyer UA. Blum M, et al. Among authors: meyer ua. Proc Natl Acad Sci U S A. 1989 Dec;86(23):9554-7. doi: 10.1073/pnas.86.23.9554. Proc Natl Acad Sci U S A. 1989. PMID: 2594784 Free PMC article.

5

In vitro characterization of the human cytochrome P-450 involved in polymorphic oxidation of propafenone.

Kroemer HK, Mikus G, Kronbach T, Meyer UA, Eichelbaum M. Kroemer HK, et al. Among authors: meyer ua. Clin Pharmacol Ther. 1989 Jan;45(1):28-33. doi: 10.1038/clpt.1989.5. Clin Pharmacol Ther. 1989. PMID: 2910635

6

Enzymatic basis of the debrisoquine/sparteine-type genetic polymorphism of drug oxidation. Characterization of bufuralol 1'-hydroxylation in liver microsomes of in vivo phenotyped carriers of the genetic deficiency.

Dayer P, Kronbach T, Eichelbaum M, Meyer UA. Dayer P, et al. Among authors: meyer ua. Biochem Pharmacol. 1987 Dec 1;36(23):4145-52. doi: 10.1016/0006-2952(87)90573-9. Biochem Pharmacol. 1987. PMID: 3689440

7

Evidence for altered catalytic properties of the cytochrome P-450 involved in sparteine oxidation in poor metabolizers.

Osikowska-Evers B, Dayer P, Meyer UA, Robertz GM, Eichelbaum M. Osikowska-Evers B, et al. Among authors: meyer ua. Clin Pharmacol Ther. 1987 Mar;41(3):320-5. doi: 10.1038/clpt.1987.34. Clin Pharmacol Ther. 1987. PMID: 3816020

8

Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism)--increased Michaelis is Constant (Km) and loss of stereoselectivity of bufuralol 1'-hydroxylation in poor metabolizers.

Dayer P, Gasser R, Gut J, Kronbach T, Robertz GM, Eichelbaum M, Meyer UA. Dayer P, et al. Among authors: meyer ua. Biochem Biophys Res Commun. 1984 Nov 30;125(1):374-80. doi: 10.1016/s0006-291x(84)80378-2. Biochem Biophys Res Commun. 1984. PMID: 6508804

9

Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression.

Blum M, Grant DM, McBride W, Heim M, Meyer UA. Blum M, et al. Among authors: meyer ua. DNA Cell Biol. 1990 Apr;9(3):193-203. doi: 10.1089/dna.1990.9.193. DNA Cell Biol. 1990. PMID: 2340091

10

Genetic polymorphisms of drug metabolism.

Meyer UA, Zanger UM, Skoda RC, Grant D, Blum M. Meyer UA, et al. Prog Liver Dis. 1990;9:307-23. Prog Liver Dis. 1990. PMID: 2156298 Review. No abstract available.

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