Spalding TA - Search Results

1

Integrative functional assays, chemical genomics and high throughput screening: harnessing signal transduction pathways to a common HTS readout.

Burstein ES, Piu F, Ma JN, Weissman JT, Currier EA, Nash NR, Weiner DM, Spalding TA, Schiffer HH, Del Tredici AL, Brann MR. Burstein ES, et al. Among authors: spalding ta. Curr Pharm Des. 2006;12(14):1717-29. doi: 10.2174/138161206776873662. Curr Pharm Des. 2006. PMID: 16712484

2

Discovery of an ectopic activation site on the M(1) muscarinic receptor.

Spalding TA, Trotter C, Skjaerbaek N, Messier TL, Currier EA, Burstein ES, Li D, Hacksell U, Brann MR. Spalding TA, et al. Mol Pharmacol. 2002 Jun;61(6):1297-302. doi: 10.1124/mol.61.6.1297. Mol Pharmacol. 2002. PMID: 12021390

3

Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor.

Ma JN, Currier EA, Essex A, Feddock M, Spalding TA, Nash NR, Brann MR, Burstein ES. Ma JN, et al. Among authors: spalding ta. Biochem Pharmacol. 2004 Apr 1;67(7):1279-84. doi: 10.1016/j.bcp.2003.11.008. Biochem Pharmacol. 2004. PMID: 15013843

4

Structure/function relationships of a G-protein coupling pocket formed by the third intracellular loop of the m5 muscarinic receptor.

Burstein ES, Spalding TA, Brann MR. Burstein ES, et al. Among authors: spalding ta. Biochemistry. 1998 Mar 24;37(12):4052-8. doi: 10.1021/bi972132j. Biochemistry. 1998. PMID: 9521726

5

The second intracellular loop of the m5 muscarinic receptor is the switch which enables G-protein coupling.

Burstein ES, Spalding TA, Brann MR. Burstein ES, et al. Among authors: spalding ta. J Biol Chem. 1998 Sep 18;273(38):24322-7. doi: 10.1074/jbc.273.38.24322. J Biol Chem. 1998. PMID: 9733718 Free article.

6

Constitutively active muscarinic receptors.

Spalding TA, Burstein ES. Spalding TA, et al. Life Sci. 2001 Apr 27;68(22-23):2511-6. doi: 10.1016/s0024-3205(01)01046-3. Life Sci. 2001. PMID: 11392620 Review.

7

5-hydroxytryptamine2A receptor inverse agonists as antipsychotics.

Weiner DM, Burstein ES, Nash N, Croston GE, Currier EA, Vanover KE, Harvey SC, Donohue E, Hansen HC, Andersson CM, Spalding TA, Gibson DF, Krebs-Thomson K, Powell SB, Geyer MA, Hacksell U, Brann MR. Weiner DM, et al. Among authors: spalding ta. J Pharmacol Exp Ther. 2001 Oct;299(1):268-76. J Pharmacol Exp Ther. 2001. PMID: 11561089

8

Constitutive activity of muscarinic acetylcholine receptors.

Spalding TA, Burstein ES. Spalding TA, et al. J Recept Signal Transduct Res. 2006;26(1-2):61-85. doi: 10.1080/10799890600567349. J Recept Signal Transduct Res. 2006. PMID: 16595339 Review.

9

Structural requirements of transmembrane domain 3 for activation by the M1 muscarinic receptor agonists AC-42, AC-260584, clozapine, and N-desmethylclozapine: evidence for three distinct modes of receptor activation.

Spalding TA, Ma JN, Ott TR, Friberg M, Bajpai A, Bradley SR, Davis RE, Brann MR, Burstein ES. Spalding TA, et al. Mol Pharmacol. 2006 Dec;70(6):1974-83. doi: 10.1124/mol.106.024901. Epub 2006 Sep 7. Mol Pharmacol. 2006. PMID: 16959945

10

AC-260584, an orally bioavailable M(1) muscarinic receptor allosteric agonist, improves cognitive performance in an animal model.

Bradley SR, Lameh J, Ohrmund L, Son T, Bajpai A, Nguyen D, Friberg M, Burstein ES, Spalding TA, Ott TR, Schiffer HH, Tabatabaei A, McFarland K, Davis RE, Bonhaus DW. Bradley SR, et al. Among authors: spalding ta. Neuropharmacology. 2010 Feb;58(2):365-73. doi: 10.1016/j.neuropharm.2009.10.003. Epub 2009 Oct 14. Neuropharmacology. 2010. PMID: 19835892

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