Moffat J - Search Results

1

A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.

Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N, Hahn WC, Lander ES, Sabatini DM, Root DE. Moffat J, et al. Cell. 2006 Mar 24;124(6):1283-98. doi: 10.1016/j.cell.2006.01.040. Cell. 2006. PMID: 16564017 Free article.

2

Building mammalian signalling pathways with RNAi screens.

Moffat J, Sabatini DM. Moffat J, et al. Nat Rev Mol Cell Biol. 2006 Mar;7(3):177-87. doi: 10.1038/nrm1860. Nat Rev Mol Cell Biol. 2006. PMID: 16496020 Review.

3

CellProfiler: image analysis software for identifying and quantifying cell phenotypes.

Carpenter AE, Jones TR, Lamprecht MR, Clarke C, Kang IH, Friman O, Guertin DA, Chang JH, Lindquist RA, Moffat J, Golland P, Sabatini DM. Carpenter AE, et al. Among authors: moffat j. Genome Biol. 2006;7(10):R100. doi: 10.1186/gb-2006-7-10-r100. Epub 2006 Oct 31. Genome Biol. 2006. PMID: 17076895 Free PMC article.

4

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.

Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM. Guertin DA, et al. Among authors: moffat j. Dev Cell. 2006 Dec;11(6):859-71. doi: 10.1016/j.devcel.2006.10.007. Dev Cell. 2006. PMID: 17141160 Free article.

5

Off-target effects associated with long dsRNAs in Drosophila RNAi screens.

Moffat J, Reiling JH, Sabatini DM. Moffat J, et al. Trends Pharmacol Sci. 2007 Apr;28(4):149-51. doi: 10.1016/j.tips.2007.02.009. Epub 2007 Mar 9. Trends Pharmacol Sci. 2007. PMID: 17350110

6

Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning.

Jones TR, Carpenter AE, Lamprecht MR, Moffat J, Silver SJ, Grenier JK, Castoreno AB, Eggert US, Root DE, Golland P, Sabatini DM. Jones TR, et al. Among authors: moffat j. Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1826-31. doi: 10.1073/pnas.0808843106. Epub 2009 Feb 2. Proc Natl Acad Sci U S A. 2009. PMID: 19188593 Free PMC article.

7

A comprehensive platform for highly multiplexed mammalian functional genetic screens.

Ketela T, Heisler LE, Brown KR, Ammar R, Kasimer D, Surendra A, Ericson E, Blakely K, Karamboulas D, Smith AM, Durbic T, Arnoldo A, Cheung-Ong K, Koh JL, Gopal S, Cowley GS, Yang X, Grenier JK, Giaever G, Root DE, Moffat J, Nislow C. Ketela T, et al. Among authors: moffat j. BMC Genomics. 2011 May 6;12:213. doi: 10.1186/1471-2164-12-213. BMC Genomics. 2011. PMID: 21548937 Free PMC article.

8

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.

Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth FP, Rissland OS, Durocher D, Angers S, Moffat J. Hart T, et al. Among authors: moffat j. Cell. 2015 Dec 3;163(6):1515-26. doi: 10.1016/j.cell.2015.11.015. Epub 2015 Nov 25. Cell. 2015. PMID: 26627737 Free article.

9

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface.

Gupta GD, Coyaud É, Gonçalves J, Mojarad BA, Liu Y, Wu Q, Gheiratmand L, Comartin D, Tkach JM, Cheung SW, Bashkurov M, Hasegan M, Knight JD, Lin ZY, Schueler M, Hildebrandt F, Moffat J, Gingras AC, Raught B, Pelletier L. Gupta GD, et al. Among authors: moffat j. Cell. 2015 Dec 3;163(6):1484-99. doi: 10.1016/j.cell.2015.10.065. Cell. 2015. PMID: 26638075 Free PMC article.

10

Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance.

Marcotte R, Sayad A, Brown KR, Sanchez-Garcia F, Reimand J, Haider M, Virtanen C, Bradner JE, Bader GD, Mills GB, Pe'er D, Moffat J, Neel BG. Marcotte R, et al. Among authors: moffat j. Cell. 2016 Jan 14;164(1-2):293-309. doi: 10.1016/j.cell.2015.11.062. Cell. 2016. PMID: 26771497 Free PMC article.

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