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Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway.
Sai K, Wang S, Balasubramaniyan V, Conrad C, Lang FF, Aldape K, Szymanski S, Fokt I, Dasgupta A, Madden T, Guan S, Chen Z, Alfred Yung WK, Priebe W, Colman H. Sai K, et al. Among authors: szymanski s. J Neurooncol. 2012 May;107(3):487-501. doi: 10.1007/s11060-011-0786-z. Epub 2012 Jan 17. J Neurooncol. 2012. PMID: 22249692
Novel small molecular inhibitors disrupt the JAK/STAT3 and FAK signaling pathways and exhibit a potent antitumor activity in glioma cells.
Swiatek-Machado K, Mieczkowski J, Ellert-Miklaszewska A, Swierk P, Fokt I, Szymanski S, Skora S, Szeja W, Grynkiewicz G, Lesyng B, Priebe W, Kaminska B. Swiatek-Machado K, et al. Among authors: szymanski s. Cancer Biol Ther. 2012 Jun;13(8):657-70. doi: 10.4161/cbt.20083. Epub 2012 Jun 1. Cancer Biol Ther. 2012. PMID: 22555804
Development of novel molecular probes of the Rio1 atypical protein kinase.
Mielecki M, Krawiec K, Kiburu I, Grzelak K, Zagórski W, Kierdaszuk B, Kowa K, Fokt I, Szymanski S, Swierk P, Szeja W, Priebe W, Lesyng B, LaRonde-LeBlanc N. Mielecki M, et al. Among authors: szymanski s. Biochim Biophys Acta. 2013 Jul;1834(7):1292-301. doi: 10.1016/j.bbapap.2013.03.012. Epub 2013 Mar 20. Biochim Biophys Acta. 2013. PMID: 23523885
145 results