Sorensen PH - Search Results

1

The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase.

Martin MJ, Melnyk N, Pollard M, Bowden M, Leong H, Podor TJ, Gleave M, Sorensen PH. Martin MJ, et al. Among authors: sorensen ph. Mol Cell Biol. 2006 Mar;26(5):1754-69. doi: 10.1128/MCB.26.5.1754-1769.2006. Mol Cell Biol. 2006. PMID: 16478996 Free PMC article.

2

A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma.

Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH. Knezevich SR, et al. Among authors: sorensen ph. Nat Genet. 1998 Feb;18(2):184-7. doi: 10.1038/ng0298-184. Nat Genet. 1998. PMID: 9462753

3

The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells.

Wai DH, Knezevich SR, Lucas T, Jansen B, Kay RJ, Sorensen PH. Wai DH, et al. Among authors: sorensen ph. Oncogene. 2000 Feb 17;19(7):906-15. doi: 10.1038/sj.onc.1203396. Oncogene. 2000. PMID: 10702799

4

The chimeric protein tyrosine kinase ETV6-NTRK3 requires both Ras-Erk1/2 and PI3-kinase-Akt signaling for fibroblast transformation.

Tognon C, Garnett M, Kenward E, Kay R, Morrison K, Sorensen PH. Tognon C, et al. Among authors: sorensen ph. Cancer Res. 2001 Dec 15;61(24):8909-16. Cancer Res. 2001. PMID: 11751416

5

ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation.

Morrison KB, Tognon CE, Garnett MJ, Deal C, Sorensen PH. Morrison KB, et al. Among authors: sorensen ph. Oncogene. 2002 Aug 22;21(37):5684-95. doi: 10.1038/sj.onc.1205669. Oncogene. 2002. PMID: 12173038

6

Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma.

Tognon C, Knezevich SR, Huntsman D, Roskelley CD, Melnyk N, Mathers JA, Becker L, Carneiro F, MacPherson N, Horsman D, Poremba C, Sorensen PH. Tognon C, et al. Among authors: sorensen ph. Cancer Cell. 2002 Nov;2(5):367-76. doi: 10.1016/s1535-6108(02)00180-0. Cancer Cell. 2002. PMID: 12450792 Free article.

7

A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin receptor substrate-1: an essential interaction for transformation.

Lannon CL, Martin MJ, Tognon CE, Jin W, Kim SJ, Sorensen PH. Lannon CL, et al. Among authors: sorensen ph. J Biol Chem. 2004 Feb 20;279(8):6225-34. doi: 10.1074/jbc.M307388200. Epub 2003 Dec 9. J Biol Chem. 2004. PMID: 14668342 Free article.

8

Mutations in the SAM domain of the ETV6-NTRK3 chimeric tyrosine kinase block polymerization and transformation activity.

Tognon CE, Mackereth CD, Somasiri AM, McIntosh LP, Sorensen PH. Tognon CE, et al. Among authors: sorensen ph. Mol Cell Biol. 2004 Jun;24(11):4636-50. doi: 10.1128/MCB.24.11.4636-4650.2004. Mol Cell Biol. 2004. PMID: 15143160 Free PMC article.

9

Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney.

Anglesio MS, Evdokimova V, Melnyk N, Zhang L, Fernandez CV, Grundy PE, Leach S, Marra MA, Brooks-Wilson AR, Penninger J, Sorensen PH. Anglesio MS, et al. Among authors: sorensen ph. Hum Mol Genet. 2004 Sep 15;13(18):2061-74. doi: 10.1093/hmg/ddh215. Epub 2004 Jul 14. Hum Mol Genet. 2004. PMID: 15254018

10

ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages.

Lannon CL, Sorensen PH. Lannon CL, et al. Among authors: sorensen ph. Semin Cancer Biol. 2005 Jun;15(3):215-23. doi: 10.1016/j.semcancer.2005.01.003. Semin Cancer Biol. 2005. PMID: 15826836 Review.

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