Drexler D - Search Results

1

Development of an on-line automated sample clean-up method and liquid chromatography-tandem mass spectrometry analysis: application in an in vitro proteolytic assay.

Drexler D, Barlow DJ, Falk P, Cantone J, Hernandez D, Ranasinghe A, Sanders M, Warrack B, McPhee F. Drexler D, et al. Anal Bioanal Chem. 2006 Mar;384(5):1145-54. doi: 10.1007/s00216-005-0263-7. Epub 2006 Feb 9. Anal Bioanal Chem. 2006. PMID: 16468024

2

Stable isotope labeling by amino acids in cell culture-based liquid chromatography-mass spectrometry assay to measure microtubule dynamics in neuronal cell cultures.

Polson C, Cantone JL, Wei C, Drexler DM, Meredith JE Jr. Polson C, et al. Anal Biochem. 2014 Dec 1;466:65-71. doi: 10.1016/j.ab.2014.08.011. Epub 2014 Aug 28. Anal Biochem. 2014. PMID: 25175011

3

Strategy to improve the quantitative LC-MS analysis of molecular ions resistant to gas-phase collision induced dissociation: application to disulfide-rich cyclic peptides.

Ciccimaro E, Ranasinghe A, D'Arienzo C, Xu C, Onorato J, Drexler DM, Josephs JL, Poss M, Olah T. Ciccimaro E, et al. Among authors: drexler dm, d arienzo c. Anal Chem. 2014 Dec 2;86(23):11523-7. doi: 10.1021/ac502678y. Epub 2014 Nov 18. Anal Chem. 2014. PMID: 25371986

4

Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and metabolites in biological tissues.

Drexler DM, Garrett TJ, Cantone JL, Diters RW, Mitroka JG, Prieto Conaway MC, Adams SP, Yost RA, Sanders M. Drexler DM, et al. J Pharmacol Toxicol Methods. 2007 May-Jun;55(3):279-88. doi: 10.1016/j.vascn.2006.11.004. Epub 2006 Dec 5. J Pharmacol Toxicol Methods. 2007. PMID: 17222568

5

An automated high throughput liquid chromatography-mass spectrometry process to assess the metabolic stability of drug candidates.

Drexler DM, Belcastro JV, Dickinson KE, Edinger KJ, Hnatyshyn SY, Josephs JL, Langish RA, McNaney CA, Santone KS, Shipkova PA, Tymiak AA, Zvyaga TA, Sanders M. Drexler DM, et al. Assay Drug Dev Technol. 2007 Apr;5(2):247-64. doi: 10.1089/adt.2006.038. Assay Drug Dev Technol. 2007. PMID: 17477833

6

Qualitative and quantitative characterization of the amyloid beta peptide (Abeta) population in biological matrices using an immunoprecipitation-LC/MS assay.

Ford MJ, Cantone JL, Polson C, Toyn JH, Meredith JE, Drexler DM. Ford MJ, et al. J Neurosci Methods. 2008 Mar 15;168(2):465-74. doi: 10.1016/j.jneumeth.2007.11.019. Epub 2007 Nov 29. J Neurosci Methods. 2008. PMID: 18187205

7

An automated liquid chromatography-mass spectrometry process to determine metabolic stability half-life and intrinsic clearance of drug candidates by substrate depletion.

McNaney CA, Drexler DM, Hnatyshyn SY, Zvyaga TA, Knipe JO, Belcastro JV, Sanders M. McNaney CA, et al. Assay Drug Dev Technol. 2008 Feb;6(1):121-9. doi: 10.1089/adt.2007.103. Assay Drug Dev Technol. 2008. PMID: 18336089

8

Application of ion trap technology to liquid chromatography/mass spectrometry quantitation of large peptides.

Shipkova P, Drexler DM, Langish R, Smalley J, Salyan ME, Sanders M. Shipkova P, et al. Rapid Commun Mass Spectrom. 2008 May;22(9):1359-66. doi: 10.1002/rcm.3511. Rapid Commun Mass Spectrom. 2008. PMID: 18381620

9

Application of quantitative LC-MS surrogate peptide methodology in the analysis of the amyloid beta peptide (Abeta) biosynthetic intermediate protein APP-betaCTF.

Cantone JL, Xu-Lin A, Toyn JH, Drexler DM. Cantone JL, et al. J Neurosci Methods. 2009 Jun 15;180(2):255-60. doi: 10.1016/j.jneumeth.2009.03.018. Epub 2009 Mar 31. J Neurosci Methods. 2009. PMID: 19464516

10

Mass spectrometry techniques for qualitative and quantitative analysis of biomarkers.

Drexler DM, Feyen JH, Sanders M. Drexler DM, et al. Drug Discov Today Technol. 2004 Sep;1(1):17-23. doi: 10.1016/j.ddtec.2004.08.010. Drug Discov Today Technol. 2004. PMID: 24981263

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