Bigge C - Search Results

1

Design, synthesis, and biological activity of novel polycyclic aza-amide FKBP12 ligands.

Hudack RA Jr, Barta NS, Guo C, Deal J, Dong L, Fay LK, Caprathe B, Chatterjee A, Vanderpool D, Bigge C, Showalter R, Bender S, Augelli-Szafran CE, Lunney E, Hou X. Hudack RA Jr, et al. Among authors: bigge c. J Med Chem. 2006 Feb 9;49(3):1202-6. doi: 10.1021/jm049161u. J Med Chem. 2006. PMID: 16451085

2

Generation of N-methyl-D-aspartate agonist and competitive antagonist pharmacophore models. Design and synthesis of phosphonoalkyl-substituted tetrahydroisoquinolines as novel antagonists.

Ortwine DF, Malone TC, Bigge CF, Drummond JT, Humblet C, Johnson G, Pinter GW. Ortwine DF, et al. Among authors: bigge cf. J Med Chem. 1992 Apr 17;35(8):1345-70. doi: 10.1021/jm00086a004. J Med Chem. 1992. PMID: 1533422

3

Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]- quinoxaline-2,3-dione and related quinoxalinediones: characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity.

Bigge CF, Malone TC, Boxer PA, Nelson CB, Ortwine DF, Schelkun RM, Retz DM, Lescosky LJ, Borosky SA, Vartanian MG, et al. Bigge CF, et al. J Med Chem. 1995 Sep 15;38(19):3720-40. doi: 10.1021/jm00019a003. J Med Chem. 1995. PMID: 7562904

4

Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARalpha/gamma dual agonists, and X-ray crystallographic studies.

Casimiro-Garcia A, Bigge CF, Davis JA, Padalino T, Pulaski J, Ohren JF, McConnell P, Kane CD, Royer LJ, Stevens KA, Auerbach BJ, Collard WT, McGregor C, Fakhoury SA, Schaum RP, Zhou H. Casimiro-Garcia A, et al. Among authors: bigge cf. Bioorg Med Chem. 2008 May 1;16(9):4883-907. doi: 10.1016/j.bmc.2008.03.043. Epub 2008 Mar 20. Bioorg Med Chem. 2008. PMID: 18394907

5

Synthesis and pharmacological evaluation of hexahydrofluorenamines as noncompetitive antagonists at the N-methyl-D-aspartate receptor.

Hays SJ, Novak PM, Ortwine DF, Bigge CF, Colbry NL, Johnson G, Lescosky LJ, Malone TC, Michael A, Reily MD, et al. Hays SJ, et al. Among authors: bigge cf. J Med Chem. 1993 Mar 19;36(6):654-70. doi: 10.1021/jm00058a002. J Med Chem. 1993. PMID: 8459395

6

Synthesis and pharmacological evaluation of 4a-phenanthrenamine derivatives acting at the phencyclidine binding site of the N-methyl-D-aspartate receptor complex.

Bigge CF, Malone TC, Hays SJ, Johnson G, Novak PM, Lescosky LJ, Retz DM, Ortwine DF, Probert AW Jr, Coughenour LL, et al. Bigge CF, et al. J Med Chem. 1993 Jul 9;36(14):1977-95. doi: 10.1021/jm00066a007. J Med Chem. 1993. PMID: 8336337

7

New and versatile approaches to the synthesis of CPP-related competitive NMDA antagonists. Preliminary structure-activity relationships and pharmacological evaluation.

Hays SJ, Bigge CF, Novak PM, Drummond JT, Bobovski TP, Rice MJ, Johnson G, Brahce LJ, Coughenour LL. Hays SJ, et al. Among authors: bigge cf. J Med Chem. 1990 Oct;33(10):2916-24. doi: 10.1021/jm00172a037. J Med Chem. 1990. PMID: 2145436

8

The discovery of glycine and related amino acid-based factor Xa inhibitors.

Kohrt JT, Filipski KJ, Cody WL, Bigge CF, La F, Welch K, Dahring T, Bryant JW, Leonard D, Bolton G, Narasimhan L, Zhang E, Peterson JT, Haarer S, Sahasrabudhe V, Janiczek N, Desiraju S, Hena M, Fiakpui C, Saraswat N, Sharma R, Sun S, Maiti SN, Leadley R, Edmunds JJ. Kohrt JT, et al. Among authors: bigge cf. Bioorg Med Chem. 2006 Jul 1;14(13):4379-92. doi: 10.1016/j.bmc.2006.02.040. Epub 2006 Mar 10. Bioorg Med Chem. 2006. PMID: 16529937

9

Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ.

Casimiro-Garcia A, Filzen GF, Flynn D, Bigge CF, Chen J, Davis JA, Dudley DA, Edmunds JJ, Esmaeil N, Geyer A, Heemstra RJ, Jalaie M, Ohren JF, Ostroski R, Ellis T, Schaum RP, Stoner C. Casimiro-Garcia A, et al. Among authors: bigge cf. J Med Chem. 2011 Jun 23;54(12):4219-33. doi: 10.1021/jm200409s. Epub 2011 May 26. J Med Chem. 2011. PMID: 21557540

10

Exploration of N-phosphonoalkyl-, N-phosphonoalkenyl-, and N-(phosphonoalkyl)phenyl-spaced alpha-amino acids as competitive N-methyl-D-aspartic acid antagonists.

Bigge CF, Johnson G, Ortwine DF, Drummond JT, Retz DM, Brahce LJ, Coughenour LL, Marcoux FW, Probert AW Jr. Bigge CF, et al. J Med Chem. 1992 Apr 17;35(8):1371-84. doi: 10.1021/jm00086a005. J Med Chem. 1992. PMID: 1533423

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