Curtis R - Search Results

1

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

Napper AD, Hixon J, McDonagh T, Keavey K, Pons JF, Barker J, Yau WT, Amouzegh P, Flegg A, Hamelin E, Thomas RJ, Kates M, Jones S, Navia MA, Saunders JO, DiStefano PS, Curtis R. Napper AD, et al. Among authors: curtis r. J Med Chem. 2005 Dec 15;48(25):8045-54. doi: 10.1021/jm050522v. J Med Chem. 2005. PMID: 16335928

2

Microplate filtration assay for nicotinamide release from NAD using a boronic acid resin.

McDonagh T, Hixon J, DiStefano PS, Curtis R, Napper AD. McDonagh T, et al. Among authors: curtis r. Methods. 2005 Aug;36(4):346-50. doi: 10.1016/j.ymeth.2005.03.005. Methods. 2005. PMID: 16085423

3

Substrate-specific activation of sirtuins by resveratrol.

Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK. Kaeberlein M, et al. Among authors: curtis r. J Biol Chem. 2005 Apr 29;280(17):17038-45. doi: 10.1074/jbc.M500655200. Epub 2005 Jan 31. J Biol Chem. 2005. PMID: 15684413 Free article.

4

Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage.

Solomon JM, Pasupuleti R, Xu L, McDonagh T, Curtis R, DiStefano PS, Huber LJ. Solomon JM, et al. Among authors: curtis r. Mol Cell Biol. 2006 Jan;26(1):28-38. doi: 10.1128/MCB.26.1.28-38.2006. Mol Cell Biol. 2006. PMID: 16354677 Free PMC article.

5

Pharmacologic inhibition of ghrelin receptor signaling is insulin sparing and promotes insulin sensitivity.

Longo KA, Govek EK, Nolan A, McDonagh T, Charoenthongtrakul S, Giuliana DJ, Morgan K, Hixon J, Zhou C, Kelder B, Kopchick JJ, Saunders JO, Navia MA, Curtis R, DiStefano PS, Geddes BJ. Longo KA, et al. Among authors: curtis r. J Pharmacol Exp Ther. 2011 Oct;339(1):115-24. doi: 10.1124/jpet.111.183764. Epub 2011 Jul 20. J Pharmacol Exp Ther. 2011. PMID: 21775475

6

Ageing and metabolism: drug discovery opportunities.

Curtis R, Geesaman BJ, DiStefano PS. Curtis R, et al. Nat Rev Drug Discov. 2005 Jul;4(7):569-80. doi: 10.1038/nrd1777. Nat Rev Drug Discov. 2005. PMID: 15976816 Review.

7

Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways.

Curtis R, O'Connor G, DiStefano PS. Curtis R, et al. Aging Cell. 2006 Apr;5(2):119-26. doi: 10.1111/j.1474-9726.2006.00205.x. Aging Cell. 2006. PMID: 16626391 Free article.

8

Insulin resistance, glycemic control and adiposity: key determinants of healthy lifespan.

DiStefano PS, Curtis R, Geddes BJ. DiStefano PS, et al. Among authors: curtis r. Curr Alzheimer Res. 2007 Apr;4(2):153-7. doi: 10.2174/156720507780362038. Curr Alzheimer Res. 2007. PMID: 17430240 Review.

9

A novel membrane potential-sensitive fluorescent dye improves cell-based assays for ion channels.

Baxter DF, Kirk M, Garcia AF, Raimondi A, Holmqvist MH, Flint KK, Bojanic D, Distefano PS, Curtis R, Xie Y. Baxter DF, et al. Among authors: curtis r. J Biomol Screen. 2002 Feb;7(1):79-85. doi: 10.1177/108705710200700110. J Biomol Screen. 2002. PMID: 11897058

10

The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans.

Apfeld J, O'Connor G, McDonagh T, DiStefano PS, Curtis R. Apfeld J, et al. Among authors: curtis r. Genes Dev. 2004 Dec 15;18(24):3004-9. doi: 10.1101/gad.1255404. Epub 2004 Dec 1. Genes Dev. 2004. PMID: 15574588 Free PMC article.

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