Lowe SW - Search Results

1

Defined genetic events associated with the spontaneous in vitro transformation of ElA/Ras-expressing human IMR90 fibroblasts.

Mason DX, Keppler D, Zhang J, Jackson TJ, Seger YR, Matsui S, Abreo F, Cowell JK, Hannon GJ, Lowe SW, Lin AW. Mason DX, et al. Among authors: lowe sw. Carcinogenesis. 2006 Feb;27(2):350-9. doi: 10.1093/carcin/bgi264. Epub 2005 Nov 9. Carcinogenesis. 2006. PMID: 16280331 Free PMC article.

2

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Serrano M, et al. Among authors: lowe sw. Cell. 1997 Mar 7;88(5):593-602. doi: 10.1016/s0092-8674(00)81902-9. Cell. 1997. PMID: 9054499 Free article.

3

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling.

Lin AW, Barradas M, Stone JC, van Aelst L, Serrano M, Lowe SW. Lin AW, et al. Among authors: lowe sw. Genes Dev. 1998 Oct 1;12(19):3008-19. doi: 10.1101/gad.12.19.3008. Genes Dev. 1998. PMID: 9765203 Free PMC article.

4

Apoptosis in cancer.

Lowe SW, Lin AW. Lowe SW, et al. Carcinogenesis. 2000 Mar;21(3):485-95. doi: 10.1093/carcin/21.3.485. Carcinogenesis. 2000. PMID: 10688869 Review.

5

Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation.

Lin AW, Lowe SW. Lin AW, et al. Among authors: lowe sw. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5025-30. doi: 10.1073/pnas.091100298. Epub 2001 Apr 17. Proc Natl Acad Sci U S A. 2001. PMID: 11309506 Free PMC article.

6

Oncogenic ras and p53 cooperate to induce cellular senescence.

Ferbeyre G, de Stanchina E, Lin AW, Querido E, McCurrach ME, Hannon GJ, Lowe SW. Ferbeyre G, et al. Among authors: lowe sw. Mol Cell Biol. 2002 May;22(10):3497-508. doi: 10.1128/MCB.22.10.3497-3508.2002. Mol Cell Biol. 2002. PMID: 11971980 Free PMC article.

7

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo.

Hemann MT, Fridman JS, Zilfou JT, Hernando E, Paddison PJ, Cordon-Cardo C, Hannon GJ, Lowe SW. Hemann MT, et al. Among authors: lowe sw. Nat Genet. 2003 Mar;33(3):396-400. doi: 10.1038/ng1091. Epub 2003 Feb 3. Nat Genet. 2003. PMID: 12567186

8

Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1).

Kondo S, Lu Y, Debbas M, Lin AW, Sarosi I, Itie A, Wakeham A, Tuan J, Saris C, Elliott G, Ma W, Benchimol S, Lowe SW, Mak TW, Thukral SK. Kondo S, et al. Among authors: lowe sw. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5431-6. doi: 10.1073/pnas.0530308100. Epub 2003 Apr 17. Proc Natl Acad Sci U S A. 2003. PMID: 12702766 Free PMC article.

9

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.

Narita M, Nũnez S, Heard E, Narita M, Lin AW, Hearn SA, Spector DL, Hannon GJ, Lowe SW. Narita M, et al. Among authors: lowe sw. Cell. 2003 Jun 13;113(6):703-16. doi: 10.1016/s0092-8674(03)00401-x. Cell. 2003. PMID: 12809602 Free article.

10

Suppression of tumorigenesis by the p53 target PUMA.

Hemann MT, Zilfou JT, Zhao Z, Burgess DJ, Hannon GJ, Lowe SW. Hemann MT, et al. Among authors: lowe sw. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9333-8. doi: 10.1073/pnas.0403286101. Epub 2004 Jun 10. Proc Natl Acad Sci U S A. 2004. PMID: 15192153 Free PMC article.

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