Sacchettini JC - Search Results

1

Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis.

Bhatt A, Kremer L, Dai AZ, Sacchettini JC, Jacobs WR Jr. Bhatt A, et al. Among authors: sacchettini jc. J Bacteriol. 2005 Nov;187(22):7596-606. doi: 10.1128/JB.187.22.7596-7606.2005. J Bacteriol. 2005. PMID: 16267284 Free PMC article.

2

Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis.

Quémard A, Sacchettini JC, Dessen A, Vilcheze C, Bittman R, Jacobs WR Jr, Blanchard JS. Quémard A, et al. Among authors: sacchettini jc. Biochemistry. 1995 Jul 4;34(26):8235-41. doi: 10.1021/bi00026a004. Biochemistry. 1995. PMID: 7599116

3

Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis.

Dessen A, Quémard A, Blanchard JS, Jacobs WR Jr, Sacchettini JC. Dessen A, et al. Among authors: sacchettini jc. Science. 1995 Mar 17;267(5204):1638-41. doi: 10.1126/science.7886450. Science. 1995. PMID: 7886450

4

Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.

Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC. Rozwarski DA, et al. Among authors: sacchettini jc. Science. 1998 Jan 2;279(5347):98-102. doi: 10.1126/science.279.5347.98. Science. 1998. PMID: 9417034

5

Crystal structure of GyrA intein from Mycobacterium xenopi reveals structural basis of protein splicing.

Klabunde T, Sharma S, Telenti A, Jacobs WR Jr, Sacchettini JC. Klabunde T, et al. Among authors: sacchettini jc. Nat Struct Biol. 1998 Jan;5(1):31-6. doi: 10.1038/nsb0198-31. Nat Struct Biol. 1998. PMID: 9437427

6

The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance.

Banerjee A, Sugantino M, Sacchettini JC, Jacobs WR. Banerjee A, et al. Among authors: sacchettini jc. Microbiology (Reading). 1998 Oct;144 ( Pt 10):2697-2704. doi: 10.1099/00221287-144-10-2697. Microbiology (Reading). 1998. PMID: 9802011 Free article.

7

Mechanisms for isoniazid action and resistance.

Miesel L, Rozwarski DA, Sacchettini JC, Jacobs WR Jr. Miesel L, et al. Among authors: sacchettini jc. Novartis Found Symp. 1998;217:209-20; discussion 220-1. doi: 10.1002/0470846526.ch15. Novartis Found Symp. 1998. PMID: 9949810 Review.

8

Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis.

Vilchèze C, Morbidoni HR, Weisbrod TR, Iwamoto H, Kuo M, Sacchettini JC, Jacobs WR Jr. Vilchèze C, et al. Among authors: sacchettini jc. J Bacteriol. 2000 Jul;182(14):4059-67. doi: 10.1128/JB.182.14.4059-4067.2000. J Bacteriol. 2000. PMID: 10869086 Free PMC article.

9

Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis.

Sharma V, Sharma S, Hoener zu Bentrup K, McKinney JD, Russell DG, Jacobs WR Jr, Sacchettini JC. Sharma V, et al. Among authors: sacchettini jc. Nat Struct Biol. 2000 Aug;7(8):663-8. doi: 10.1038/77964. Nat Struct Biol. 2000. PMID: 10932251

10

Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase.

McKinney JD, Höner zu Bentrup K, Muñoz-Elías EJ, Miczak A, Chen B, Chan WT, Swenson D, Sacchettini JC, Jacobs WR Jr, Russell DG. McKinney JD, et al. Among authors: sacchettini jc. Nature. 2000 Aug 17;406(6797):735-8. doi: 10.1038/35021074. Nature. 2000. PMID: 10963599

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