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Page 1
Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily.
Caruthers J, Zucker F, Worthey E, Myler PJ, Buckner F, Van Voorhuis W, Mehlin C, Boni E, Feist T, Luft J, Gulde S, Lauricella A, Kaluzhniy O, Anderson L, Le Trong I, Holmes MA, Earnest T, Soltis M, Hodgson KO, Hol WG, Merritt EA. Caruthers J, et al. Among authors: lauricella a. Protein Sci. 2005 Nov;14(11):2887-94. doi: 10.1110/ps.051783005. Epub 2005 Sep 30. Protein Sci. 2005. PMID: 16199669 Free PMC article.
Structure of Lmaj006129AAA, a hypothetical protein from Leishmania major.
Arakaki T, Le Trong I, Phizicky E, Quartley E, DeTitta G, Luft J, Lauricella A, Anderson L, Kalyuzhniy O, Worthey E, Myler PJ, Kim D, Baker D, Hol WG, Merritt EA. Arakaki T, et al. Among authors: lauricella a. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Mar 1;62(Pt 3):175-9. doi: 10.1107/S1744309106005902. Epub 2006 Feb 24. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006. PMID: 16511295 Free PMC article.
Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase.
Bosch J, Robien MA, Mehlin C, Boni E, Riechers A, Buckner FS, Van Voorhis WC, Myler PJ, Worthey EA, DeTitta G, Luft JR, Lauricella A, Gulde S, Anderson LA, Kalyuzhniy O, Neely HM, Ross J, Earnest TN, Soltis M, Schoenfeld L, Zucker F, Merritt EA, Fan E, Verlinde CL, Hol WG. Bosch J, et al. Among authors: lauricella a. J Med Chem. 2006 Oct 5;49(20):5939-46. doi: 10.1021/jm060429m. J Med Chem. 2006. PMID: 17004709
Structure of a Trypanosoma brucei alpha/beta-hydrolase fold protein with unknown function.
Merritt EA, Holmes M, Buckner FS, Van Voorhis WC, Quartly E, Phizicky EM, Lauricella A, Luft J, DeTitta G, Neely H, Zucker F, Hol WG. Merritt EA, et al. Among authors: lauricella a. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 1;64(Pt 6):474-8. doi: 10.1107/S174430910801141X. Epub 2008 May 16. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008. PMID: 18540054 Free PMC article.
Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.
Larson ET, Deng W, Krumm BE, Napuli A, Mueller N, Van Voorhis WC, Buckner FS, Fan E, Lauricella A, DeTitta G, Luft J, Zucker F, Hol WG, Verlinde CL, Merritt EA. Larson ET, et al. Among authors: lauricella a. J Mol Biol. 2008 Sep 12;381(4):975-88. doi: 10.1016/j.jmb.2008.06.048. Epub 2008 Jun 24. J Mol Biol. 2008. PMID: 18602399 Free PMC article.
The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase.
Larson ET, Mudeppa DG, Gillespie JR, Mueller N, Napuli AJ, Arif JA, Ross J, Arakaki TL, Lauricella A, Detitta G, Luft J, Zucker F, Verlinde CL, Fan E, Van Voorhis WC, Buckner FS, Rathod PK, Hol WG, Merritt EA. Larson ET, et al. Among authors: lauricella a. J Mol Biol. 2010 Mar 12;396(5):1244-59. doi: 10.1016/j.jmb.2010.01.013. Epub 2010 Jan 11. J Mol Biol. 2010. PMID: 20070944 Free PMC article.
Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site.
Robien MA, Bosch J, Buckner FS, Van Voorhis WC, Worthey EA, Myler P, Mehlin C, Boni EE, Kalyuzhniy O, Anderson L, Lauricella A, Gulde S, Luft JR, DeTitta G, Caruthers JM, Hodgson KO, Soltis M, Zucker F, Verlinde CL, Merritt EA, Schoenfeld LW, Hol WG. Robien MA, et al. Among authors: lauricella a. Proteins. 2006 Mar 15;62(3):570-7. doi: 10.1002/prot.20801. Proteins. 2006. PMID: 16345073
The structure of Plasmodium vivax phosphatidylethanolamine-binding protein suggests a functional motif containing a left-handed helix.
Arakaki T, Neely H, Boni E, Mueller N, Buckner FS, Van Voorhis WC, Lauricella A, DeTitta G, Luft J, Hol WG, Merritt EA. Arakaki T, et al. Among authors: lauricella a. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Mar 1;63(Pt 3):178-82. doi: 10.1107/S1744309107007580. Epub 2007 Feb 23. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007. PMID: 17329808 Free PMC article.
Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum.
Holmes MA, Buckner FS, Van Voorhis WC, Mehlin C, Boni E, Earnest TN, DeTitta G, Luft J, Lauricella A, Anderson L, Kalyuzhniy O, Zucker F, Schoenfeld LW, Hol WG, Merritt EA. Holmes MA, et al. Among authors: lauricella a. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Mar 1;62(Pt 3):180-5. doi: 10.1107/S1744309106005847. Epub 2006 Feb 24. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006. PMID: 16511296 Free PMC article.
Structure of a ribulose 5-phosphate 3-epimerase from Plasmodium falciparum.
Caruthers J, Bosch J, Buckner F, Van Voorhis W, Myler P, Worthey E, Mehlin C, Boni E, DeTitta G, Luft J, Lauricella A, Kalyuzhniy O, Anderson L, Zucker F, Soltis M, Hol WG. Caruthers J, et al. Among authors: lauricella a. Proteins. 2006 Feb 1;62(2):338-42. doi: 10.1002/prot.20764. Proteins. 2006. PMID: 16304640
70 results