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Page 1
Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents.
Biftu T, Feng D, Ponpipom M, Girotra N, Liang GB, Qian X, Bugianesi R, Simeone J, Chang L, Gurnett A, Liberator P, Dulski P, Leavitt PS, Crumley T, Misura A, Murphy T, Rattray S, Samaras S, Tamas T, Mathew J, Brown C, Thompson D, Schmatz D, Fisher M, Wyvratt M. Biftu T, et al. Bioorg Med Chem Lett. 2005 Jul 1;15(13):3296-301. doi: 10.1016/j.bmcl.2005.04.060. Bioorg Med Chem Lett. 2005. PMID: 15922595
Synthesis and SAR studies of very potent imidazopyridine antiprotozoal agents.
Biftu T, Feng D, Fisher M, Liang GB, Qian X, Scribner A, Dennis R, Lee S, Liberator PA, Brown C, Gurnett A, Leavitt PS, Thompson D, Mathew J, Misura A, Samaras S, Tamas T, Sina JF, McNulty KA, McKnight CG, Schmatz DM, Wyvratt M. Biftu T, et al. Bioorg Med Chem Lett. 2006 May 1;16(9):2479-83. doi: 10.1016/j.bmcl.2006.01.092. Epub 2006 Feb 7. Bioorg Med Chem Lett. 2006. PMID: 16464591
Synthesis and SAR studies of diarylpyrrole anticoccidial agents.
Qian X, Liang GB, Feng D, Fisher M, Crumley T, Rattray S, Dulski PM, Gurnett A, Leavitt PS, Liberator PA, Misura AS, Samaras S, Tamas T, Schmatz DM, Wyvratt M, Biftu T. Qian X, et al. Among authors: misura as. Bioorg Med Chem Lett. 2006 May 15;16(10):2817-21. doi: 10.1016/j.bmcl.2006.01.041. Epub 2006 Mar 6. Bioorg Med Chem Lett. 2006. PMID: 16517161
Synthesis and SAR studies of potent imidazopyridine anticoccidial agents.
Liang GB, Qian X, Feng D, Fisher M, Brown CM, Gurnett A, Leavitt PS, Liberator PA, Misura AS, Tamas T, Schmatz DM, Wyvratt M, Biftu T. Liang GB, et al. Among authors: misura as. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3558-61. doi: 10.1016/j.bmcl.2007.04.041. Epub 2007 Apr 24. Bioorg Med Chem Lett. 2007. PMID: 17475489
N-alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives with heterocyclic substitutions as potent and broad spectrum anticoccidial agents.
Liang GB, Qian X, Feng D, Fisher M, Crumley T, Darkin-Rattray SJ, Dulski PM, Gurnett A, Leavitt PS, Liberator PA, Misura AS, Samaras S, Tamas T, Schmatz DM, Wyvratt M, Biftu T. Liang GB, et al. Among authors: misura as. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2019-22. doi: 10.1016/j.bmcl.2008.01.104. Epub 2008 Feb 2. Bioorg Med Chem Lett. 2008. PMID: 18276140
Isolation, structure, and coccidiostat activity of coccidiostatin A.
Jayasuriya H, Guan Z, Dombrowski AW, Bills GF, Polishook JD, Jenkins RG, Koch L, Crumley T, Tamas T, Dubois M, Misura A, Darkin-Rattray SJ, Gregory L, Singh SB. Jayasuriya H, et al. J Nat Prod. 2007 Aug;70(8):1364-7. doi: 10.1021/np0700523. Epub 2007 Jul 17. J Nat Prod. 2007. PMID: 17636951
Purification and molecular characterization of cGMP-dependent protein kinase from Apicomplexan parasites. A novel chemotherapeutic target.
Gurnett AM, Liberator PA, Dulski PM, Salowe SP, Donald RG, Anderson JW, Wiltsie J, Diaz CA, Harris G, Chang B, Darkin-Rattray SJ, Nare B, Crumley T, Blum PS, Misura AS, Tamas T, Sardana MK, Yuan J, Biftu T, Schmatz DM. Gurnett AM, et al. Among authors: misura as. J Biol Chem. 2002 May 3;277(18):15913-22. doi: 10.1074/jbc.M108393200. Epub 2002 Feb 7. J Biol Chem. 2002. PMID: 11834729 Free article.
20 results