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Page 1
Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents.
Biftu T, Feng D, Ponpipom M, Girotra N, Liang GB, Qian X, Bugianesi R, Simeone J, Chang L, Gurnett A, Liberator P, Dulski P, Leavitt PS, Crumley T, Misura A, Murphy T, Rattray S, Samaras S, Tamas T, Mathew J, Brown C, Thompson D, Schmatz D, Fisher M, Wyvratt M. Biftu T, et al. Among authors: crumley t. Bioorg Med Chem Lett. 2005 Jul 1;15(13):3296-301. doi: 10.1016/j.bmcl.2005.04.060. Bioorg Med Chem Lett. 2005. PMID: 15922595
Synthesis and SAR studies of diarylpyrrole anticoccidial agents.
Qian X, Liang GB, Feng D, Fisher M, Crumley T, Rattray S, Dulski PM, Gurnett A, Leavitt PS, Liberator PA, Misura AS, Samaras S, Tamas T, Schmatz DM, Wyvratt M, Biftu T. Qian X, et al. Among authors: crumley t. Bioorg Med Chem Lett. 2006 May 15;16(10):2817-21. doi: 10.1016/j.bmcl.2006.01.041. Epub 2006 Mar 6. Bioorg Med Chem Lett. 2006. PMID: 16517161
N-alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives with heterocyclic substitutions as potent and broad spectrum anticoccidial agents.
Liang GB, Qian X, Feng D, Fisher M, Crumley T, Darkin-Rattray SJ, Dulski PM, Gurnett A, Leavitt PS, Liberator PA, Misura AS, Samaras S, Tamas T, Schmatz DM, Wyvratt M, Biftu T. Liang GB, et al. Among authors: crumley t. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2019-22. doi: 10.1016/j.bmcl.2008.01.104. Epub 2008 Feb 2. Bioorg Med Chem Lett. 2008. PMID: 18276140
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1.
Colletti SL, Myers RW, Darkin-Rattray SJ, Gurnett AM, Dulski PM, Galuska S, Allocco JJ, Ayer MB, Li C, Lim J, Crumley TM, Cannova C, Schmatz DM, Wyvratt MJ, Fisher MH, Meinke PT. Colletti SL, et al. Among authors: crumley tm. Bioorg Med Chem Lett. 2001 Jan 22;11(2):107-11. doi: 10.1016/s0960-894x(00)00604-1. Bioorg Med Chem Lett. 2001. PMID: 11206438
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2.
Colletti SL, Myers RW, Darkin-Rattray SJ, Gurnett AM, Dulski PM, Galuska S, Allocco JJ, Ayer MB, Li C, Lim J, Crumley TM, Cannova C, Schmatz DM, Wyvratt MJ, Fisher MH, Meinke PT. Colletti SL, et al. Among authors: crumley tm. Bioorg Med Chem Lett. 2001 Jan 22;11(2):113-7. doi: 10.1016/s0960-894x(00)00605-3. Bioorg Med Chem Lett. 2001. PMID: 11206439
Purification and molecular characterization of cGMP-dependent protein kinase from Apicomplexan parasites. A novel chemotherapeutic target.
Gurnett AM, Liberator PA, Dulski PM, Salowe SP, Donald RG, Anderson JW, Wiltsie J, Diaz CA, Harris G, Chang B, Darkin-Rattray SJ, Nare B, Crumley T, Blum PS, Misura AS, Tamas T, Sardana MK, Yuan J, Biftu T, Schmatz DM. Gurnett AM, et al. Among authors: crumley t. J Biol Chem. 2002 May 3;277(18):15913-22. doi: 10.1074/jbc.M108393200. Epub 2002 Feb 7. J Biol Chem. 2002. PMID: 11834729 Free article.
Isolation, structure, and coccidiostat activity of coccidiostatin A.
Jayasuriya H, Guan Z, Dombrowski AW, Bills GF, Polishook JD, Jenkins RG, Koch L, Crumley T, Tamas T, Dubois M, Misura A, Darkin-Rattray SJ, Gregory L, Singh SB. Jayasuriya H, et al. Among authors: crumley t. J Nat Prod. 2007 Aug;70(8):1364-7. doi: 10.1021/np0700523. Epub 2007 Jul 17. J Nat Prod. 2007. PMID: 17636951
Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.
Darkin-Rattray SJ, Gurnett AM, Myers RW, Dulski PM, Crumley TM, Allocco JJ, Cannova C, Meinke PT, Colletti SL, Bednarek MA, Singh SB, Goetz MA, Dombrowski AW, Polishook JD, Schmatz DM. Darkin-Rattray SJ, et al. Among authors: crumley tm. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13143-7. doi: 10.1073/pnas.93.23.13143. Proc Natl Acad Sci U S A. 1996. PMID: 8917558 Free PMC article.
25 results