Karki RG - Search Results

1

Model of full-length HIV-1 integrase complexed with viral DNA as template for anti-HIV drug design.

Karki RG, Tang Y, Burke TR Jr, Nicklaus MC. Karki RG, et al. J Comput Aided Mol Des. 2004 Dec;18(12):739-60. doi: 10.1007/s10822-005-0365-5. Epub 2005 Jun 27. J Comput Aided Mol Des. 2004. PMID: 16075307

2

Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors.

Zhang X, Pais GC, Svarovskaia ES, Marchand C, Johnson AA, Karki RG, Nicklaus MC, Pathak VK, Pommier Y, Burke TR. Zhang X, et al. Among authors: karki rg. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1215-9. doi: 10.1016/s0960-894x(03)00059-3. Bioorg Med Chem Lett. 2003. PMID: 12643946

3

Metal-dependent inhibition of HIV-1 integrase by beta-diketo acids and resistance of the soluble double-mutant (F185K/C280S).

Marchand C, Johnson AA, Karki RG, Pais GC, Zhang X, Cowansage K, Patel TA, Nicklaus MC, Burke TR Jr, Pommier Y. Marchand C, et al. Among authors: karki rg. Mol Pharmacol. 2003 Sep;64(3):600-9. doi: 10.1124/mol.64.3.600. Mol Pharmacol. 2003. PMID: 12920196

4

Virtual screening application of a model of full-length HIV-1 integrase complexed with viral DNA.

Liao C, Karki RG, Marchand C, Pommier Y, Nicklaus MC. Liao C, et al. Among authors: karki rg. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5361-5. doi: 10.1016/j.bmcl.2007.08.011. Epub 2007 Aug 11. Bioorg Med Chem Lett. 2007. PMID: 17719223

5

Metal-dependent inhibition of HIV-1 integrase.

Neamati N, Lin Z, Karki RG, Orr A, Cowansage K, Strumberg D, Pais GC, Voigt JH, Nicklaus MC, Winslow HE, Zhao H, Turpin JA, Yi J, Skalka AM, Burke TR Jr, Pommier Y. Neamati N, et al. Among authors: karki rg. J Med Chem. 2002 Dec 19;45(26):5661-70. doi: 10.1021/jm0201417. J Med Chem. 2002. PMID: 12477350

6

Mass spectrometric analysis of the HIV-1 integrase-pyridoxal 5'-phosphate complex reveals a new binding site for a nucleotide inhibitor.

Williams KL, Zhang Y, Shkriabai N, Karki RG, Nicklaus MC, Kotrikadze N, Hess S, Le Grice SF, Craigie R, Pathak VK, Kvaratskhelia M. Williams KL, et al. Among authors: karki rg. J Biol Chem. 2005 Mar 4;280(9):7949-55. doi: 10.1074/jbc.M413579200. Epub 2004 Dec 22. J Biol Chem. 2005. PMID: 15615720 Free article.

7

Design and synthesis of conformationally constrained Grb2 SH2 domain binding peptides employing alpha-methylphenylalanyl based phosphotyrosyl mimetics.

Oishi S, Karki RG, Kang SU, Wang X, Worthy KM, Bindu LK, Nicklaus MC, Fisher RJ, Burke TR Jr. Oishi S, et al. Among authors: karki rg. J Med Chem. 2005 Feb 10;48(3):764-72. doi: 10.1021/jm0492709. J Med Chem. 2005. PMID: 15689160

8

Utilization of a nitrobenzoxadiazole (NBD) fluorophore in the design of a Grb2 SH2 domain-binding peptide mimetic.

Shi ZD, Karki RG, Oishi S, Worthy KM, Bindu LK, Dharmawardana PG, Nicklaus MC, Bottaro DP, Fisher RJ, Burke TR Jr. Shi ZD, et al. Among authors: karki rg. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1385-8. doi: 10.1016/j.bmcl.2005.01.017. Bioorg Med Chem Lett. 2005. PMID: 15713392

9

Evaluation of macrocyclic Grb2 SH2 domain-binding peptide mimetics prepared by ring-closing metathesis of C-terminal allylglycines with an N-terminal beta-vinyl-substituted phosphotyrosyl mimetic.

Oishi S, Karki RG, Shi ZD, Worthy KM, Bindu L, Chertov O, Esposito D, Frank P, Gillette WK, Maderia M, Hartley J, Nicklaus MC, Barchi JJ Jr, Fisher RJ, Burke TR Jr. Oishi S, et al. Among authors: karki rg. Bioorg Med Chem. 2005 Apr 1;13(7):2431-8. doi: 10.1016/j.bmc.2005.01.052. Bioorg Med Chem. 2005. PMID: 15755645

10

Application of azide-alkyne cycloaddition 'click chemistry' for the synthesis of Grb2 SH2 domain-binding macrocycles.

Choi WJ, Shi ZD, Worthy KM, Bindu L, Karki RG, Nicklaus MC, Fisher RJ, Burke TR Jr. Choi WJ, et al. Among authors: karki rg. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5265-9. doi: 10.1016/j.bmcl.2006.08.004. Bioorg Med Chem Lett. 2006. PMID: 16908148 Free PMC article.

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