Increased "absence" of telomeres may indicate Alzheimer's disease/dementia status in older individuals with Down syndrome.
Jenkins EC, Ye L, Gu H, Ni SA, Duncan CJ, Velinov M, Pang D, Krinsky-McHale SJ, Zigman WB, Schupf N, Silverman WP.
Jenkins EC, et al. Among authors: gu h.
Neurosci Lett. 2008 Aug 8;440(3):340-3. doi: 10.1016/j.neulet.2008.05.098. Epub 2008 Jun 18.
Neurosci Lett. 2008.
PMID: 18571319
Free PMC article.
We have reported previously that telomeres (ends of chromosomes consisting of highly conserved TTAGGG repeats) were shorter in metaphase and interphase preparations in T lymphocytes from short-term whole blood cultures of women with Down syndrome (DS) and dementia compared to age …
We have reported previously that telomeres (ends of chromosomes consisting of highly conserved TTAGGG repeats) were shorter in metaphase and …