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Page 1
Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.
Nallan L, Bauer KD, Bendale P, Rivas K, Yokoyama K, Hornéy CP, Pendyala PR, Floyd D, Lombardo LJ, Williams DK, Hamilton A, Sebti S, Windsor WT, Weber PC, Buckner FS, Chakrabarti D, Gelb MH, Van Voorhis WC. Nallan L, et al. Among authors: horney cp. J Med Chem. 2005 Jun 2;48(11):3704-13. doi: 10.1021/jm0491039. J Med Chem. 2005. PMID: 15916422
Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase.
Van Voorhis WC, Rivas KL, Bendale P, Nallan L, Hornéy C, Barrett LK, Bauer KD, Smart BP, Ankala S, Hucke O, Verlinde CL, Chakrabarti D, Strickland C, Yokoyama K, Buckner FS, Hamilton AD, Williams DK, Lombardo LJ, Floyd D, Gelb MH. Van Voorhis WC, et al. Antimicrob Agents Chemother. 2007 Oct;51(10):3659-71. doi: 10.1128/AAC.00246-07. Epub 2007 Jul 2. Antimicrob Agents Chemother. 2007. PMID: 17606674 Free PMC article.
Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation.
Fletcher S, Cummings CG, Rivas K, Katt WP, Hornéy C, Buckner FS, Chakrabarti D, Sebti SM, Gelb MH, Van Voorhis WC, Hamilton AD. Fletcher S, et al. J Med Chem. 2008 Sep 11;51(17):5176-97. doi: 10.1021/jm800113p. Epub 2008 Aug 8. J Med Chem. 2008. PMID: 18686940 Free PMC article.