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Combined α2- and D2-receptor blockade activates noradrenergic and dopaminergic neurons, but extracellular dopamine in the prefrontal cortex is determined by uptake and release from noradrenergic terminals.
Sagheddu C, Devoto P, Aroni S, Saba P, Pistis M, Gessa GL. Sagheddu C, et al. Among authors: devoto p. Front Pharmacol. 2023 Aug 23;14:1238115. doi: 10.3389/fphar.2023.1238115. eCollection 2023. Front Pharmacol. 2023. PMID: 37680715 Free PMC article.
Prenatal THC exposure produces a hyperdopaminergic phenotype rescued by pregnenolone.
Frau R, Miczán V, Traccis F, Aroni S, Pongor CI, Saba P, Serra V, Sagheddu C, Fanni S, Congiu M, Devoto P, Cheer JF, Katona I, Melis M. Frau R, et al. Among authors: devoto p. Nat Neurosci. 2019 Dec;22(12):1975-1985. doi: 10.1038/s41593-019-0512-2. Epub 2019 Oct 14. Nat Neurosci. 2019. PMID: 31611707 Free PMC article.
The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson's disease patients.
Nuzzo T, Punzo D, Devoto P, Rosini E, Paciotti S, Sacchi S, Li Q, Thiolat ML, Véga C, Carella M, Carta M, Gardoni F, Calabresi P, Pollegioni L, Bezard E, Parnetti L, Errico F, Usiello A. Nuzzo T, et al. Among authors: devoto p. Sci Rep. 2019 Jun 20;9(1):8898. doi: 10.1038/s41598-019-45419-1. Sci Rep. 2019. PMID: 31222058 Free PMC article.
89 results