Lai JC - Search Results

1

Phosphorothioate oligodeoxynucleotides and G3139 induce apoptosis in 518A2 melanoma cells.

Lai JC, Benimetskaya L, Khvorova A, Wu S, Hua E, Miller P, Stein CA. Lai JC, et al. Mol Cancer Ther. 2005 Feb;4(2):305-15. Mol Cancer Ther. 2005. PMID: 15713901

2

Bcl-2 protein in 518A2 melanoma cells in vivo and in vitro.

Benimetskaya L, Ayyanar K, Kornblum N, Castanotto D, Rossi J, Wu S, Lai J, Brown BD, Popova N, Miller P, McMicken H, Chen Y, Stein CA. Benimetskaya L, et al. Clin Cancer Res. 2006 Aug 15;12(16):4940-8. doi: 10.1158/1078-0432.CCR-06-1002. Clin Cancer Res. 2006. PMID: 16914583

3

Antisense RNA down-regulation of bcl-2 expression in DU145 prostate cancer cells does not diminish the cytostatic effects of G3139 (Oblimersen).

Raffo A, Lai JC, Stein CA, Miller P, Scaringe S, Khvorova A, Benimetskaya L. Raffo A, et al. Among authors: lai jc. Clin Cancer Res. 2004 May 1;10(9):3195-206. doi: 10.1158/1078-0432.ccr-03-0287. Clin Cancer Res. 2004. PMID: 15131061

4

Changes in gene expression induced by phosphorothioate oligodeoxynucleotides (including G3139) in PC3 prostate carcinoma cells are recapitulated at least in part by treatment with interferon-beta and -gamma.

Benimetskaya L, Wittenberger T, Stein CA, Hofmann HP, Weller C, Lai JC, Miller P, Gekeler V. Benimetskaya L, et al. Among authors: lai jc. Clin Cancer Res. 2004 Jun 1;10(11):3678-88. doi: 10.1158/1078-0432.CCR-03-0569. Clin Cancer Res. 2004. PMID: 15173074

5

Relative Bcl-2 independence of drug-induced cytotoxicity and resistance in 518A2 melanoma cells.

Benimetskaya L, Lai JC, Khvorova A, Wu S, Hua E, Miller P, Zhang LM, Stein CA. Benimetskaya L, et al. Among authors: lai jc. Clin Cancer Res. 2004 Dec 15;10(24):8371-9. doi: 10.1158/1078-0432.CCR-04-1294. Clin Cancer Res. 2004. PMID: 15623615

6

Induction of apoptosis by G3139 in melanoma cells.

Benimetskaya L, Lai JC, Khvorova A, Wu S, Miller P, Stein CA. Benimetskaya L, et al. Among authors: lai jc. Ann N Y Acad Sci. 2005 Nov;1058:235-45. doi: 10.1196/annals.1359.033. Ann N Y Acad Sci. 2005. PMID: 16394140 Review.

7

A pharmacologic target of G3139 in melanoma cells may be the mitochondrial VDAC.

Lai JC, Tan W, Benimetskaya L, Miller P, Colombini M, Stein CA. Lai JC, et al. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7494-9. doi: 10.1073/pnas.0602217103. Epub 2006 Apr 28. Proc Natl Acad Sci U S A. 2006. PMID: 16648253 Free PMC article.

8

Comparison of d-g3139 and its enantiomer L-g3139 in melanoma cells demonstrates minimal in vitro but dramatic in vivo chiral dependency.

Lai JC, Brown BD, Voskresenskiy AM, Vonhoff S, Klussman S, Tan W, Colombini M, Weeratna R, Miller P, Benimetskaya L, Stein CA. Lai JC, et al. Mol Ther. 2007 Feb;15(2):270-8. doi: 10.1038/sj.mt.6300037. Mol Ther. 2007. PMID: 17235304 Free article.

9

Phosphorothioate oligonucleotides reduce mitochondrial outer membrane permeability to ADP.

Tan W, Lai JC, Miller P, Stein CA, Colombini M. Tan W, et al. Among authors: lai jc. Am J Physiol Cell Physiol. 2007 Apr;292(4):C1388-97. doi: 10.1152/ajpcell.00490.2006. Epub 2006 Nov 29. Am J Physiol Cell Physiol. 2007. PMID: 17135295 Free article.

10

Protamine-fragment peptides fused to an SV40 nuclear localization signal deliver oligonucleotides that produce antisense effects in prostate and bladder carcinoma cells.

Benimetskaya L, Guzzo-Pernell N, Liu ST, Lai JC, Miller P, Stein CA. Benimetskaya L, et al. Among authors: lai jc. Bioconjug Chem. 2002 Mar-Apr;13(2):177-87. doi: 10.1021/bc010068j. Bioconjug Chem. 2002. PMID: 11906253

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