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Combined inhibition of class 1-PI3K-alpha and delta isoforms causes senolysis by inducing p21WAF1/CIP1 proteasomal degradation in senescent cells.
Neuwahl J, Neumann CA, Fitz AC, Biermann AD, Magel M, Friedrich A, Sellin L, Stork B, Piekorz RP, Proksch P, Budach W, Jänicke RU, Sohn D. Neuwahl J, et al. Among authors: neumann ca. Cell Death Dis. 2024 May 29;15(5):373. doi: 10.1038/s41419-024-06755-x. Cell Death Dis. 2024. PMID: 38811535 Free PMC article.
Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies.
Hong L, Braden DC, Zhao Y, Skoko JJ, Chang F, Woodcock SR, Uvalle C, Casey A, Wood K, Salvatore SR, Asan A, Harkness T, Fagunloye A, Razzaghi M, Straub A, Spies M, Brown DD, Lee AV, Schopfer F, Freeman BA, Neumann CA. Hong L, et al. Among authors: neumann ca. bioRxiv [Preprint]. 2023 Aug 14:2023.08.11.552990. doi: 10.1101/2023.08.11.552990. bioRxiv. 2023. Update in: Redox Biol. 2023 Oct;66:102856. doi: 10.1016/j.redox.2023.102856 PMID: 37645906 Free PMC article. Updated. Preprint.
Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies.
Hong L, Braden DC, Zhao Y, Skoko JJ, Chang F, Woodcock SR, Uvalle C, Casey A, Wood K, Salvatore SR, Asan A, Harkness T, Fagunloye A, Razzaghi M, Straub A, Spies M, Brown DD, Lee AV, Schopfer F, Freeman BA, Neumann CA. Hong L, et al. Among authors: neumann ca. Redox Biol. 2023 Oct;66:102856. doi: 10.1016/j.redox.2023.102856. Epub 2023 Aug 19. Redox Biol. 2023. PMID: 37633047 Free PMC article.
Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1.
Skoko JJ, Cao J, Gaboriau D, Attar M, Asan A, Hong L, Paulsen CE, Ma H, Liu Y, Wu H, Harkness T, Furdui CM, Manevich Y, Morrison CG, Brown ET, Normolle D, Spies M, Spies MA, Carroll K, Neumann CA. Skoko JJ, et al. Among authors: neumann ca. Redox Biol. 2022 Oct;56:102443. doi: 10.1016/j.redox.2022.102443. Epub 2022 Aug 24. Redox Biol. 2022. PMID: 36058112 Free PMC article.
39 results